Hypertension Clinical Trial
— DREWOfficial title:
Dose-response to Exercise in Women Aged 45-75 Years (DREW)
Verified date | September 2022 |
Source | Pennington Biomedical Research Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
To investigate the effects of different amounts of exercise on both cardiorespiratory fitness and risk factors for cardiovascular disease in sedentary, overweight, mildly hypertensive, but healthy, postmenopausal women aged 45 to 75 years.
Status | Completed |
Enrollment | 464 |
Est. completion date | December 2006 |
Est. primary completion date | December 2006 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 45 Years to 75 Years |
Eligibility | Postmenopausal women aged 45 to 75 years who are overweight or obese (body mass index of 25 to 40 kg/m2) and have normal or mildly elevated BP. |
Country | Name | City | State |
---|---|---|---|
United States | Oak Cliff-South Dallas | Dallas | Texas |
United States | The Cooper Institute | Dallas | Texas |
Lead Sponsor | Collaborator |
---|---|
Pennington Biomedical Research Center | National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Jordan AN, Jurca GM, Locke CT, Church TS, Blair SN. Pedometer indices for weekly physical activity recommendations in postmenopausal women. Med Sci Sports Exerc. 2005 Sep;37(9):1627-32. — View Citation
Jurca R, Church TS, Morss GM, Jordan AN, Earnest CP. Eight weeks of moderate-intensity exercise training increases heart rate variability in sedentary postmenopausal women. Am Heart J. 2004 May;147(5):e21. — View Citation
Morss GM, Jordan AN, Skinner JS, Dunn AL, Church TS, Earnest CP, Kampert JB, Jurca R, Blair SN. Dose Response to Exercise in Women aged 45-75 yr (DREW): design and rationale. Med Sci Sports Exerc. 2004 Feb;36(2):336-44. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | VO2max and resting systolic blood pressure | at 6 months | ||
Secondary | Fasting blood lipids and lipoproteins (total, HDL-, and LDL-cholesterol, triglycerides | at 6 months | ||
Secondary | High sensitive C-reactive protein | at 6 months | ||
Secondary | Fasting glucose | at 6 months | ||
Secondary | Anthropometry (body composition and regional fat distribution) | at 6 months | ||
Secondary | Blood pressure response to exercise | at 6 months | ||
Secondary | Heart rate variability | at 6 months | ||
Secondary | Health-related quality of life and other psychosocial variables | at 6 months | ||
Secondary | Cardiovascular disease risk determined by a multiple logistic risk function | at 6 months | ||
Secondary | Tertiary Outcomes | Other variables of interest include dietary habits, physical activity history, smoking, alcohol intake, sleep habits, medication use (including HRT), demographic characteristics, unstructured physical activity, menstrual history, and personal and family medical history. | at 6 months |
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