Hypertension Clinical Trial
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk African-American populations
BACKGROUND:
Although hypertension is a predisposing factor for end stage renal disease, the underlying
hypothesis of this study was that in select African-American families genetic factors
predisposed them to develop ESRD in the face of hypertension. An inherited basis for H-ESRD
was supported by familial clustering of H-ESRD among African Americans that could not be
explained by socioeconomic status, access to medical care, and the prevalence of diabetes
and hypertension.
DESIGN NARRATIVE:
DNA samples were collected, identified, and clinically characterized from African-American
sib-pairs (and other family members with hypertensive end-stage renal disease). This aspect
of the study was based on the fact that Dr. Freedman, the principal investigator, had
already developed a unique "family history of end-stage renal disease" database
independently funded by the End-Stage Renal Disease Network Six. This registry served as a
very large and unique collection of African-American end-stage renal disease patients. He
began with a candidate gene approach for linkage to hypertensive end-stage renal disease in
his patient samples using a variety of growth factor genes, genes involved in sodium
transport and vascular tone, as well as human homologues of rodent genes that had, or were
to be identified in the future as contributing to ESRD in that organism. If this initial
first pass of candidate genes failed to demonstrate linkage to hypertensive end-stage renal
disease, a systematic genome-wide scan was to be performed with available simple sequence
length polymorphisms (SSLP) and other polymorphic markers. Hypertensive end-stage renal
disease is a condition of enormous clinical and economic importance and identification of
associated or causative renal-failure genes would form a genetic basis for the detection of
high-risk individuals and assist in development of intervention and treatment strategies to
prevent this condition.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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