Hypertension Clinical Trial
To examine a school-based population of children for maturational changes in blood pressure and cardiac structures.
BACKGROUND:
Although excessive left ventricular mass has been viewed as an adaptation to increased blood
pressure, it can precede the rise in blood pressure in hypertensive models. Excessive growth
of the heart may reflect additional factors contributing to eventual level of blood
pressure. In children, rapid heart growth may be predictive of subsequent high childhood
blood pressure level and greater incidence of cardiovascular disease in adult relatives.
These studies had the potential of defining maturational changes in known risk factors which
might help predict future hypertensive disease.
The study was a subproject within a Specialized Center of Research (SCOR) in Hypertension.
The Request for Applications for the SCOR was released in October, 1988.
DESIGN NARRATIVE:
A total of 124 prepubertal males and females were followed longitudinally for five years.
Yearly examinations defined the stages of sexual maturation. On four occasions each year,
subjects were studied for resting and ambulatory blood pressure, echocardiography,
anthropometry and activity assessment. Once yearly, each subject had blood drawn for hormone
analyses and whole blood viscosity estimate. From these data, growth velocities of the heart
and rate of change of blood pressure were determined. These parameters were analyzed to
determine if rapid growth of the heart preceded or followed the rise in blood pressure
observed during puberty and body size and composition, sexual maturation and hormone
changes, and sympathetic activity.
The study was a subproject within a SCOR in Hypertension. Approximately 7 percent of total
dollars were awarded for this subproject.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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