Hypertension Clinical Trial
To identify and study a large cohort of glucocorticoid remediable aldosteronism (GRA) patients.
DESIGN NARRATIVE:
The spectrum of the severity and the natural history of the disorder was characterized.
Modifying environmental and genetic factors important in regulation of blood pressure were
determined. Also, renal physiology was studied in GRA patients to determine how these
patients escaped hypokalemia in spite of mineralocorticoid excess. There were four specific
aims including: 1) to determine the natural history and prevalence of GRA in various
hypertensive populations, 2) to characterize the magnitude of effect imparted on blood
pressure by inheritance of GRA and the sources of variation in phenotype expression of the
hypertension, 3) to investigate the renal and hormonal mechanisms regulating potassium
conservation and loss in GRA, and 4) to characterize the disequilibrium of GRA with Irish
and Scottish descent and specific alleles of the aldosterone synthase gene.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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