Hypertension Clinical Trial
To determine the prevalence and longitudinal course of sleep apnea among men and women and to examine the associations of apnea, oxygen desaturation, snoring, high blood pressure, and other biomedical correlates.
BACKGROUND:
Sleep apnea is characterized by repetitive cessations of respiration during sleep with
consequent decreases in arterial oxygen saturation. Sleep apnea can be caused by upper
airway obstruction or by central nervous system failure to sufficiently excite the diaphragm
and accessory respiratory muscles. However, in most cases, both processes are involved.
Hypopneas, in which airflow is significantly compromised without complete cessations of
respiratory flow, and snoring are often found in association with apneas. Both apneas and
hypopneas cause repetitive disruptions of sleep, consequent daytime somnolence, and complex
cardio-respiratory disturbances.
DESIGN NARRATIVE:
The study was longitudinal in design. A stratified random sample of adults in San Diego was
used to examine risk factors in the prevalence of sleep respiratory disturbances. A
structured random sample was selected by random digit telephone dialing. Subjects were
studied in their homes. Some were followed yearly during the project. Each volunteer gave a
brief sleep history and medical review, including blood pressure measurement, the National
Interview Survey, And Quality of Well-being Scale. Blood oxygen saturation, pulse rate,
snoring, and sleep duration were recorded for three nights. State-of-the-art computerized
pulse oximeters and microprocessor-based activity/light monitors were used. Subjects found
to have the most severe sleep respiratory disturbances underwent laboratory polysomnograms
to add descriptive data and to validate the survey methodology. The prevalence of
respiratory disturbances in sleep was analyzed as a function of age and sex. Associations
with several aspects of morbidity were determined. The longitudinal course of respiratory
disturbances in sleep were examined.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
;
N/A
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |