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NCT05328921 Clinical Trial

Effects of Systemic Drugs on Intraocular Pressure

Hypertension Clinical Trial

Official title:
Effects of Two Systemic Drugs on Intraocular Pressure in Narrow Angle Glaucoma

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05328921
Other study ID # Rc 9-22
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 7, 2022
Est. completion date September 30, 2022

Study information
Verified date April 2022
Source Benha University
Contact Ahmed Abdelshafy, MD
Phone 01222328766
Email ahmad4lg@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

Description:

Changes in intraocular pressure in glaucomatous patients with narrow angle may elicit attacks of angle closure glaucoma. In this study we aim to assess changes in intraocular pressure (IOP) among glaucomatous patients on systemic antihypertensive and antihistaminic drugs.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date September 30, 2022
Est. primary completion date September 15, 2022
Accepts healthy volunteers
Gender All
Age group 35 Years to 70 Years
Eligibility Inclusion Criteria: - patients with narrow angle glaucoma on systemic antihypertensive and/or antihistaminic drugs. Exclusion Criteria: - open angle glaucoma patients confirmed by gonioscopy examination. - Cases with dense corneal opacity or iris trauma that may affects gonioscopy examination. - cases with secondary glaucoma.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Antihypertensive Agents
Patients with narrow angle glaucoma and on systemic antihypertensive drugs.
• Antihistaminics
Patients with narrow angle glaucoma and on systemic antihistaminic drugs.

Locations
Country Name City State
Egypt Ahmed Abdelshafy Banha QA

Sponsors (1)
Lead Sponsor Collaborator
Benha University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Changes in intraocular pressure (IOP) measured by applanation tonometry Changes in IOP measured by millimeter mercury (mmHg) Immediately after visual acuity assessment for each eye after topical anesthetic eye drops and again on one and three months visit
Secondary Changes in pupil diameter Size of pupil measured in millimeters (mm) 7sing autorefractometer Immediately after slit lamp examination and again on one and three months visit
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