Integrated Hypertension and HIV Care Cascades in Uganda

Hypertension Clinical Trial

Official title:

Integrated Hypertension and HIV Care Cascades in a HIV Treatment Program in Eastern Uganda: a Retrospective Cohort Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03605043
• Other study ID #: ss 4583
• Status: Completed
• Start date: January 1, 2014
• Est. completion date: May 30, 2018

Study information

• Verified date: July 2018
• Source: Makerere University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In this retrospective cohort study, we mapped the care cascades for both Hypertension and HIV within a HIV program in Uganda with the goal of identifying opportunities for developing contextually appropriate integrated care models, .

Description:

Persons living with HIV (PLHIV) and receiving anti-retroviral therapy (ART) are at increased risk of cardiovascular disease (CVD) due to direct effects of ART and HIV infection itself, compounded by traditional CVD risk factors such as increased life expectancy and Westernized diet. Additionally, in sub-Saharan Africa, as is the case globally, hypertension (HTN) is a major risk factor for CVD. The prevalence of HTN in the setting of HIV reported in the literature is variable but may be higher than in the HIV-negative population.

World Health Organization (WHO) and Ugandan national HIV guidelines have recommended the integration of hypertension care into HIV programs since 2014 and 2016, but there has been limited uptake of this recommendation in practice. There have been successful efforts to integrate tuberculosis, malaria, nutrition, maternal-child health, and family planning into HIV programmes in Uganda. In this study, with the goal of identifying opportunities for developing contextually appropriate integrated care models, we mapped the care cascades for both HTN and HIV within a HIV program in Uganda.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1649
• Est. completion date: May 30, 2018
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years of age and above, Having started Antiretroviral therapy between January 2014 and January 2017.

Exclusion Criteria:

• PLHIV receiving treatment from clinics other than the 3 selected sites.

Related Conditions & MeSH terms

• HIV
• Hypertension

Intervention

Other:
• Blood pressure management in the HIV program
Integrated care for hypertension and HIV in the HIV program

Locations

Country	Name	City	State
Uganda	Makerere University College of Health Sciences	Kampala	Central

Sponsors (1)

Lead Sponsor	Collaborator
Makerere University

Country where clinical trial is conducted

Uganda, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood pressure control	Blood pressure control among Persons living with both HIV and hypertension. Achieving Blood pressure of <140/90mmHg	1 year
Secondary	HIV control	HIV control among persons living with both HIV and hypertension. Defined as HIV Viral suppression. Viral load of <1000 copies/mL	1 year