Hypertension Clinical Trial
Official title:
The Effect of Remote Ischaemic Conditioning on Blood Pressure Control in Patients With Chronic Kidney Disease - the ERIC-BP-CKD Trial
Chronic kidney disease (CKD) is one of the leading causes of death and disability in Singapore and worldwide. Hypertension is commonly inadequately controlled in patients with CKD and this is associated with CKD progression and cardiovascular complications. Daily episodes of Remote ischaemic conditioning (termed chronic RIC or CRIC) using transient limb ischaemia/reperfusion applied for 1 to 12 months have been shown to lower systemic blood pressure (SBP), prevent stroke and reduce post-myocardial infarction left ventricular (LV) remodelling in experimental and clinical studies. In the ERIC-BP-CKD feasibility and efficacy study, we hypothesise that CRIC administered for 28 days will lower systemic blood pressure and improve blood pressure control in patients with CKD and hypertension.
Chronic kidney disease (CKD) is one of the leading causes of death and disability in
Singapore and worldwide. CKD patients often suffer with inadequately controlled hypertension,
the presence of which is associated with cardiovascular complications such as left
ventricular (LV) hypertrophy, cardiac failure, and stroke. As such, novel treatments are
required to improve blood pressure control in order to improve health outcomes in CKD
patients.
Remote ischaemic conditioning (RIC) using transient limb ischaemia/reperfusion has been shown
to protect the kidney and microvasculature in experimental and clinical studies, and daily
episodes of RIC (termed chronic RIC or CRIC) applied for 1 to 12 months have been shown to
lower systemic blood pressure (SBP), prevent stroke and reduce post-myocardial infarction
left ventricular (LV) remodelling in experimental and clinical studies. Whether CRIC can
reduce SBP in hypertensive patients with CKD is not known. In the ERIC-BP-CKD feasibility and
efficacy study, we hypothesise that CRIC administered for 28 days will lower systemic blood
pressure and improve blood pressure control in patients with CKD and hypertension.
In this study, subjects will be randomised in a 1:1 ratio to receive therapy from either the
active autoRIC® Device or identical sham autoRIC® Device.
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