Hypertension Clinical Trial
Official title:
Randomized Controlled Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure
The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic basis, causes more intraoperative hypotension (low blood pressure) during surgery. Our hypothesis is that the usual practice of continuing furosemide on the day of surgery would contribute to more hypotension during surgery than discontinuing furosemide.
A significant proportion of patients who undergo surgery take medications on a chronic
basis. Little is known about the effects of these medications on the successful conduct of
anesthesia and surgery. Diuretics like furosemide may contribute to low blood pressure
during surgery, an outcome associated with cardiovascular complications. However, many
patients are recommended to take their diuretics on the day of surgery. We wished to
determine if preoperative administration of furosemide contributes to intraoperative
hypotension compared to placebo.
Comparison: We conducted a randomized, double blind placebo controlled trial to compare the
effect of furosemide with that of placebo on intraoperative hypotension using intraoperative
blood pressure recordings in patients who take furosemide chronically and were undergoing
noncardiac surgery.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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