Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

Hypersensitivity Pneumonitis Clinical Trial

Official title:

Study of Nasal Mucosa Histopathological Changes in Patients With Chronic Hypersensitivity Pneumonitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05723796
• Other study ID #: MD-138-2021
• Status: Completed
• Phase: N/A
• Start date: July 1, 2021
• Est. completion date: December 15, 2022

Study information

• Verified date: February 2023
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa.

Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: December 15, 2022
• Est. primary completion date: October 31, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 29 Years to 55 Years

Eligibility

Inclusion Criteria:

• all patients with clinical and radiological features of HP

Exclusion Criteria:

• respiratory failure

• patients on anticoagulants

Related Conditions & MeSH terms

• Alveolitis, Extrinsic Allergic
• Hypersensitivity
• Hypersensitivity Pneumonitis
• Pneumonia

Intervention

Procedure:
• nasal endoscopy
nasal endoscopy and mucosal biopsy

Locations

Country	Name	City	State
Egypt	Kasr alainy school of medicine	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy	nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations	6 months