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NCT05723796 Clinical Trial

Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

Hypersensitivity Pneumonitis Clinical Trial

Official title:
Study of Nasal Mucosa Histopathological Changes in Patients With Chronic Hypersensitivity Pneumonitis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05723796
Other study ID # MD-138-2021
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 1, 2021
Est. completion date December 15, 2022

Study information
Verified date February 2023
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa. Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date December 15, 2022
Est. primary completion date October 31, 2022
Accepts healthy volunteers No
Gender All
Age group 29 Years to 55 Years
Eligibility Inclusion Criteria: - all patients with clinical and radiological features of HP Exclusion Criteria: - respiratory failure - patients on anticoagulants

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• nasal endoscopy
nasal endoscopy and mucosal biopsy

Locations
Country Name City State
Egypt Kasr alainy school of medicine Cairo

Sponsors (1)
Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations 6 months
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