Hypercholesterolemia Clinical Trial
Official title:
Effect of LDL-apheresis on Pentraxin3 Plasma Levels in Hypercholesterolemic Patients With Coronary Artery Disease
Inflammation plays a major role in atherosclerosis. Pentraxin 3 (PTX3) a multifunctional
pattern-recognition protein, is expressed in many tissues/cells, including innate immunity
cells, endothelium and atherosclerotic plaques. Its role is controversial: it may exert
protective cardiovascular effects and/or it may be an indicator of plaque vulnerability and
future cardiovascular risk.
LDL-Apheresis removes apoB100-containing lipoproteins and it can prevent progression of
coronary artery disease (CAD). LDL-Apheresis exerts non-lipidic beneficial effects on the
procoagulatory state and on hemorheology. No data exist about the effects of LDL-Apheresis
on plasma PTX3 levels.
Hypercholesterolemic patients with documented CAD, on chronic fortnightly LDL-apheresis
treatment will be enrolled in this study.
Blood samples will be collected before and after a single LDL-Apheresis treatment to asses
PTX3, HsCRP, IL6, IL10, Fibrinogen and lipid plasma levels.
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Observational Model: Case-Only, Time Perspective: Prospective
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