Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03235518 |
Other study ID # |
AAAR0256 |
Secondary ID |
R01MH110051 |
Status |
Completed |
Phase |
|
First received |
|
Last updated |
|
Start date |
June 28, 2017 |
Est. completion date |
April 4, 2018 |
Study information
Verified date |
January 2022 |
Source |
Columbia University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
The purpose of this study is to conduct formative research to inform the design and
implementation of combination prevention interventions, including pre-exposure prophylaxis
(PrEP) for female sex workers (FSW), as well as to inform recruitment and retention
strategies for female sex workers and their male clients in Kenya.
Description:
Despite remarkable advances in the global HIV response with 17 million persons, out of nearly
37 million living with HIV, who have initiated antiretroviral therapy (ART) in low- and
middle-income countries (LMIC) as of end of 2015, there were an estimated 5,700 new HIV
infections each day and a total of 2.1 million new HIV infections in 2015, of which 66% were
in sub-Saharan Africa (SSA). Key populations within the generalized HIV epidemics in SSA,
including female sex workers (FSW), have received insufficient attention, with data
indicating that they are at disproportionate risk with limited access to prevention and
treatment services. Globally, new infections among key populations and their sexual partners
accounted for 36% of all new HIV infections in 2015. HIV prevalence among FSW is 29.3%
worldwide. While reliable HIV prevalence estimates are lacking, younger FSW <25 years may be
at significantly greater risk due to the confluence of biological, behavioral and structural
risk factors.6 Mathematical modeling suggests that the proportion of new HIV infections
attributable to sex work is likely to increase over time.
In settings where key populations contribute substantially to HIV burden, as in Kenya,
effective integrated prevention strategies are urgently needed for populations such as FSW
and can have a substantial impact on reducing new HIV infections.
In 2012, HIV prevalence among Kenyan 15-64 year olds was 5.6%, with 1,192,000 people living
with HIV, but was markedly higher (15.1%) in the region of Kenya, formerly named Nyanza
Province. HIV prevalence is 14.1% among FSW and 7.6% among male clients of sex workers (MC).
FSW contribute significantly to new HIV infections in Kenya,14 with modelled estimates
showing that 1 in 3 new HIV infections can be attributed to key populations.