Pulmonary Function at Presentation and Follow-up in Hemato-Oncology 3-7 Years Old Children

Acute Lymphoblastic Leukemia Clinical Trial

Official title: Pulmonary Function at Presentation and Follow-up in Hemato-Oncology 3-7 Years

Status Completed

Clinical Trial Summary

The aim of this study was to investigate the occurrences of respiratory symptoms risk factors and abnormalities in lung function in young children (3-6 years old) with hemato-oncologic diseases at presentation (before treatment) and up to 3 years follow-up (study period).

Clinical Trial Description

Pulmonary function tests (PFTs) are a part of the routine follow-up of patients receiving anti-cancer treatment. Treatment is frequently associated with diverse pulmonary damage which may become functionally and clinically evident many years later. PFTs may help to quantify the damage in the lungs; help to evaluate the point at which lung function deviates from normal to allow early intervention before irreversible lung damage occurs and thereby to reduce morbidity and mortality.

Reliable PFTs in the preschool age have traditionally been difficult to perform, but recent publications have demonstrated that the majority of preschool children can produce reproducible forced expiratory flow volume (FEVC) curves with proper coaching techniques. This recent development may enable studying the long term effect (years) of treatment on lung function in young children suffering from hemato-oncologic diseases. ;

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Acute Lymphoblastic Leukemia
• Acute Myeloblastic Leukemia
• Hodgkin Disease
• Hodgkin's Disease
• Leukemia
• Leukemia, Lymphoid
• Leukemia, Myeloid
• Leukemia, Myeloid, Acute
• Non-Malignant
• Precursor Cell Lymphoblastic Leukemia-Lymphoma
• Solid Tumors,

• NCT number: NCT00552825
• Study type: Observational
• Source: Sheba Medical Center
• Status: Completed
• Phase: N/A
• Start date: October 2005
• Completion date: October 2006