HIV Clinical Trial
Official title:
Systems Biological Responses to Influenza Vaccination in an HIV-infected and HIV-uninfected Adult Population in Kampala, Uganda
To use a systems biological approach to study the molecular signatures of innate and adaptive responses to vaccination in a HIV infected versus uninfected adult population in Kampala, Uganda.
This longitudinal, observational cohort study will be conducted at the Makerere University-
Johns Hopkins University Research Collaboration, at the Mulago National Referral Hospital
complex in Kampala Uganda. The study will consist of 2 groups. One group will consist of 25
healthy HIV uninfected adults and the other arm will consist of 35 HIV infected adults.
Within the HIV infected arm there will be two groups, 25 HIV infected adults and 10 long
term non-progressors. Vaccinees will receive a primary immunization at day 0, and blood
samples will be obtained at days 0, 1, 3, 7, 14, 28 and 100 after immunization.
We will analyze the early molecular signatures (identified by microarray analyses, as well
as by FACS analyses of innate immune cells and luminex analyses of cytokines and chemokines)
that correlate and predict the later immune responses.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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