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Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection

HIV Infection Clinical Trial

Official title:
Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection

Clinical Trial Summary

The objective of the present study is to analyze the overall tubular function, and in particular that from the proximal tubule and the thick ascending loop of Henle (TALH) in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with seronegative controls, by applying a validated tubular physiological test known as "Low sodium infusion test".

Hypothesis is that patients with HIV infection and normal renal function will show subclinical tubular abnormalities compared with seronegative controls

Clinical Trial Description

Renal disease is a well recognized complication among patients with HIV infection. Either viral infection itself and the use of some antiretroviral drugs contribute to this serious non AIDS-defining condition that may affect both the glomeruli and the renal tubules.

The thick ascending loop of Henle constitutes the main location for free-water clearance determining kidney´s ability to concentrate and dilute urine in a direct and indirect fashion, respectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01869010
Study type Observational
Source Hospital Italiano de Buenos Aires
Contact
Status Completed
Phase N/A
Start date January 2010
Completion date April 2012
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