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Trial of Probiotics to Lower Microbial Translocation and Immune Activation in HIV-Infected Adolescents

HIV Infection Clinical Trial

Official title:
A Randomized Placebo-Controlled Trial of Probiotics to Lower Microbial Translocation and Immune Activation in HIV-Infected Adolescents

Clinical Trial Summary

This is a randomized placebo-controlled trial to examine if once daily probiotic therapy will lower serum LPS levels and immune activation among HIV-infected youth.

Clinical Trial Description

This is a double masked randomized placebo-controlled trial to examine if once daily probiotic therapy will lower serum lipopolysaccharide (LPS) levels and immune activation among HIV-infected youth. The study will enroll two cohorts: (1) a cohort of subjects who are not receiving antiretroviral therapy (ART) and have absolute CD4 T-cell count greater than 350 cells/ul and quantitative HIV-1 plasma RNA (viral load) less than 50,000 copies/ml; and (2) a cohort of subjects who are receiving ART and have absolute CD4 T-cell count greater than 350 cells/ul and and quantitative HIV-1 plasma RNA (viral load) less than 400 copies/ml. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01492803
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Withdrawn
Phase N/A
Start date December 2011
Completion date December 2012
View Details
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