Diffusion MRI in Heart Failure

Status Recruiting

Clinical Trial Summary

The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with MRI will allow its microstructure to be resolved. The investigators further hypothesize that the characterization of microstructural changes in the heart will help elucidate the pathogenesis of heart failure and the transition from a compensated to a decompensated state. Patients with recent myocardial infarcts and left ventricular hypertrophy, who are at risk for the development of heart failure, will be enrolled. The participants will undergo serial diffusion tensor MRI (DTI) imaging of the heart to characterize changes in myocardial microstructure over time.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02973633
Study type	Interventional
Source	Massachusetts General Hospital
Contact	David E. Sosnovik, MD
Phone	617-724-3407
Email	sosnovik@nmr.mgh.harvard.edu
Status	Recruiting
Phase	Early Phase 1
Start date	June 30, 2017
Completion date	December 31, 2022

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