Heart Failure Clinical Trial
Official title:
Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects
The investigators propose a small pilot proof of concept study to not only prove the existence of, but also probe the mechanisms underlying cardio-renal effects of empagliflozin in patients with heart failure. The investigators propose a 50 patient randomized, double-blind, placebo-controlled crossover study with patients with stable HF, type II diabetes and an eGFR >45ml/min/1.73 m2 who are chronically receiving loop diuretics.
Study Objectives
1. Study the acute/short term effect and cardio-renal mechanisms of sodium-glucose
cotransporter 2 (SGLT2) inhibition in patients with heart failure.
2. Determine the effect of chronic combined SLLGT2 and loop diuretic exposure in patients
with heart failure.
Primary Outcomes
1. Aim 1 (Acute): Determine if acute SGLT2 inhibition will improve the natriuretic effect
of a loop diuretic compared to placebo.
2. Aim 2 (Chronic): Determine the effect of 14 days of SGLT2 inhibition on blood volume.
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