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NCT06119009 Clinical Trial

New-onset Heart Blocks After Noncardiac Surgery: a Retrospective Study of More Than 280,000 Patients

Heart Block Clinical Trial

Official title:
New-onset Heart Blocks After Noncardiac Surgery: a Retrospective Study of More Than 280,000 Patients

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06119009
Other study ID # ChinesePLAGH301NBBB
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2008
Est. completion date August 1, 2019

Study information
Verified date October 2023
Source Chinese PLA General Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aimed to investigate new-onset heart blocks after noncardiac surgery, identify risk factors, and develop a prediction model.

Description:

Objective: This study aimed to investigate new-onset heart blocks after noncardiac surgery, identify risk factors, and develop a prediction model. Methods: A retrospective cohort study included 281,497 patients aged 18 or older who underwent noncardiac surgery at a single center between Jan 2008 and Aug 2019. The main outcome was postoperative new-onset heart blocks within one year, including atrioventricular and bundle blocks. Prognostic impact was assessed using Kaplan-Meier survival curves and time-dependent Cox regression analysis. Perioperative data was used for machine learning models (logistic regression, support vector machine, random forest, decision tree). Model performance was measured using the area under the receiver operating characteristic curve (AUC).

Recruitment information / eligibility
Status Completed
Enrollment 281497
Est. completion date August 1, 2019
Est. primary completion date August 1, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - patients above 18 yrs undergoing noncardiac surgery at the First Medical Center of the Chinese People's Liberation Army General Hospital (PLAGH) from January 1, 2008 to August 1, 2019. Exclusion Criteria: - surgical duration of less than 30 minutes - incomplete data

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• non interventions

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Chinese PLA General Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary New-onset heart blocks The number of new-onset heart blocks within one year after surgery, including first-, second-, and third-degree AV blocks and left- and right-branch bundle blocks within one year after surgery
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