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SV2 PET Imaging With [11C]APP311 — SV2  

Healthy Clinical Trial

Official title:
Synaptic Density in Psychiatric Disorders Using SV2A Receptor PET Imaging With [11C]APP311

Clinical Trial Summary

The aim of this study is to evaluate a new SV2A tracer, [11C]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.

Clinical Trial Description

The overall goal of this protocol is to study synaptic density in two psychiatric disorders (namely schizophrenia and other psychotic disorders, and cannabis use disorder) with this exciting new PET tracer. Secondary outcomes will include electroencephalography (EEG). A battery of EEG paradigms assessing sensory, perceptual, and cognitive functions will also be administered. The primary dependent measures will be traditional event related potentials (ERPs; e.g. latency and amplitude) as well as time X frequency analysis (inter-trial coherence and spectral power). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03995121
Study type Observational
Source Yale University
Contact Rachel Hird, BS
Phone 203-974-7775
Email rachel.hird@yale.edu
Status Recruiting
Phase
Start date December 1, 2017
Completion date December 2025
View Details
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