Healthy Clinical Trial
— BBPPOfficial title:
Brain/Behavior Alterations in Pediatric Psychopathology
The purpose of this research is to learn more about how children with mental health problems, including bipolar disorder (BD), attention deficit hyperactivity disorder (ADHD), and generalized anxiety disorder (GAD), differ from children without these problems. The investigators want to understand how these 4 groups of children differ in brain activity, function, and structure.
Status | Recruiting |
Enrollment | 240 |
Est. completion date | December 2018 |
Est. primary completion date | December 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 7 Years to 17 Years |
Eligibility |
General Inclusion Criteria: - English- speaking,children & adolescents between the ages of 7- 17 - consenting parent/guardian General Exclusion Criteria: - estimated IQ less than 70 - substance/alcohol use or dependence within the last 2 months - Autism Spectrum Disorders or primary psychosis - medical/neurological conditions that mimic the psychiatric disorders of interest - implanted metal (NO BRACES or COCHLEAR IMPLANT) For inclusion in the Bipolar group, participants: - have to meet Diagnostic and Statistical Manual, 4th Edition Text Revision (DSM-IV-TR) criteria for BD Type I, including at least one lifetime episode of mania For inclusion in the ADHD/ADD group, participants: - meet DSM-IV-TR criteria for any subtype of ADHD or ADD - can not currently meet diagnostic criteria for bipolar, depressive or anxiety disorders For inclusion in the Generalized Anxiety Group (GAD), participants: - have to meet DSM-IV-TR criteria for GAD - can not currently meet diagnostic criteria for Obsessive Compulsive Disorder (OCD) or Post-Traumatic Stress Disorder (PTSD) For inclusion in the Healthy Control group, participants: - can not have a past/current history of psychiatric or substance use disorders - can not have a first-degree relative (parents, brothers/sisters) with a history of psychiatric illness |
Country | Name | City | State |
---|---|---|---|
United States | Bradley Hospital | East Providence | Rhode Island |
Lead Sponsor | Collaborator |
---|---|
Bradley Hospital | National Institute of Mental Health (NIMH) |
United States,
Dickstein DP, Gorrostieta C, Ombao H, Goldberg LD, Brazel AC, Gable CJ, Kelly C, Gee DG, Zuo XN, Castellanos FX, Milham MP. Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry. 2010 Nov 1;68(9): — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Behavioral performance on computerized tasks | Day 1 | ||
Primary | MRI data (neural activation) during behavioral task | structural, functional and diffusion tensor imaging data will be collected during the second day of the study. | Day 2 | |
Secondary | Genetic material | Genetic samples (spit sample) will be examined in relation to neural activation, function, and structure as well as behavioral performance on computerized tasks. | Day 1 |
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