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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01570426
Other study ID # 0195-07
Secondary ID K22MH074945
Status Recruiting
Phase N/A
First received March 27, 2012
Last updated January 16, 2018
Start date July 2007
Est. completion date December 2018

Study information

Verified date January 2018
Source Bradley Hospital
Contact PediMIND Program
Phone 401-432-1600
Email pedimind@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this research is to learn more about how children with mental health problems, including bipolar disorder (BD), attention deficit hyperactivity disorder (ADHD), and generalized anxiety disorder (GAD), differ from children without these problems. The investigators want to understand how these 4 groups of children differ in brain activity, function, and structure.


Description:

This study has 2 visits (total time ~6 hours):

Visit #1 (2-3 hours), includes: (a) detailed description of study and study consent, (b) interviews about the child's mental health, mood, and behavior, and (c) a screening IQ test (word games, playing with blocks).

If a child fits our study criteria, they will play some special computer games, provide a spit sample for DNA, and parents/children will complete questionnaires.

All children fitting our study criteria, will also be invited to complete visit #2 (2 hours) consisting of a special MRI brain scan at Brown University (Providence, RI). To make sure all children feel comfortable in the MRI, they will spend time in our practice MRI (i.e., "MRI simulator") that looks and sounds just like the real MRI. During the actual MRI, children will play a computerized game in which they can win and lose points. The MRI lasts one and a half hours (at most).

Participants are compensated for their time.


Recruitment information / eligibility

Status Recruiting
Enrollment 240
Est. completion date December 2018
Est. primary completion date December 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 7 Years to 17 Years
Eligibility General Inclusion Criteria:

- English- speaking,children & adolescents between the ages of 7- 17

- consenting parent/guardian

General Exclusion Criteria:

- estimated IQ less than 70

- substance/alcohol use or dependence within the last 2 months

- Autism Spectrum Disorders or primary psychosis

- medical/neurological conditions that mimic the psychiatric disorders of interest

- implanted metal (NO BRACES or COCHLEAR IMPLANT)

For inclusion in the Bipolar group, participants:

- have to meet Diagnostic and Statistical Manual, 4th Edition Text Revision (DSM-IV-TR) criteria for BD Type I, including at least one lifetime episode of mania

For inclusion in the ADHD/ADD group, participants:

- meet DSM-IV-TR criteria for any subtype of ADHD or ADD

- can not currently meet diagnostic criteria for bipolar, depressive or anxiety disorders

For inclusion in the Generalized Anxiety Group (GAD), participants:

- have to meet DSM-IV-TR criteria for GAD

- can not currently meet diagnostic criteria for Obsessive Compulsive Disorder (OCD) or Post-Traumatic Stress Disorder (PTSD)

For inclusion in the Healthy Control group, participants:

- can not have a past/current history of psychiatric or substance use disorders

- can not have a first-degree relative (parents, brothers/sisters) with a history of psychiatric illness

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
United States Bradley Hospital East Providence Rhode Island

Sponsors (2)

Lead Sponsor Collaborator
Bradley Hospital National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Dickstein DP, Gorrostieta C, Ombao H, Goldberg LD, Brazel AC, Gable CJ, Kelly C, Gee DG, Zuo XN, Castellanos FX, Milham MP. Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry. 2010 Nov 1;68(9): — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Behavioral performance on computerized tasks Day 1
Primary MRI data (neural activation) during behavioral task structural, functional and diffusion tensor imaging data will be collected during the second day of the study. Day 2
Secondary Genetic material Genetic samples (spit sample) will be examined in relation to neural activation, function, and structure as well as behavioral performance on computerized tasks. Day 1
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