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Circadian Rhythmicity in Cold-induced Thermogenesis — COLDR  

Healthy Clinical Trial

Official title:
The Impact of Circadian Rhythmicity in Cold-induced Thermogenesis in Lean and Obese Subjects

Clinical Trial Summary

This study aims to investigate whether maximum cold-induced non-shivering thermogenesis (e.g. thermogenesis as a consequence of BAT activity) differs between morning and evening.

Clinical Trial Description

Brown adipose tissue (BAT) recently emerged as a novel player in energy expenditure (EE) in humans as it combusts fatty acids and glucose towards heat. Human BAT can be activated by sympathetic stimulation resulting from cold exposure or treatment with sympathomimetic drugs. Short-term acclimation to mild cold was shown to reduce fat mass in obese subjects and decrease peripheral insulin resistance of patients with T2DM. Recently, in preclinical studies the investigators showed that BAT has a circadian rhythm. It is currently unknown whether this is also the case in humans. The investigators postulate that BAT activity should display a circadian rhythm that adapts to changes in circadian behavior, and may determine glucose/lipid levels throughout the day. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04406922
Study type Interventional
Source Leiden University Medical Center
Contact
Status Completed
Phase N/A
Start date April 23, 2019
Completion date January 1, 2021
View Details
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