Healthy Subjects Clinical Trial
Official title:
Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol
Levels of tocotrienol in human tissues following supplementation is not currently known. The objective of this present study is to determine the levels of this form of vitamin E in the human tissues such as skin, heart, lung, liver, adipose tissue, Brain and cerebrospinal fluid (CSF) following oral supplementation
In nature, there are eight members in the vitamin E family: a-, b-, g- and d-TCP, and a-,
b-, g- and d-tocotrienol (TCT). Vitamin E research has developed highly asymmetrically. Out
of the 25,000+ papers on vitamin E in the PubMed, 99% deal with tocopherols. Recent research
has demonstrated the lack of cancer-preventive effects and potential adverse health
consequences of tocopherol (6). As a result, more attention has been turned towards
non-tocopherol forms of vitamin E (16). Palm oil represents a major source of natural TCT.
TCT possess powerful neuroprotective, antioxidant, anti-cancer and cholesterol lowering
properties that often differ from the properties of TCP (15).
During the last five years, our and other laboratories have reported several striking
beneficial properties of tocotrienols in experimental settings. One major concern that
limits enthusiasm for tocotrienol for humans is the report that the vitamin E transporting
protein, tocopherol-transport protein (TTP), has a very low affinity to transport
tocotrienol. Using TTP-knock out mice, we have recently demonstrated that oral TCT is
effectively carried to vital organs and that such transport can take place independent of
TTP. With that background, the purpose of this project is to test the hypothesis that orally
supplemented tocotrienol reaches the vital organs of humans.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)
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