Hypertension Clinical Trial
Official title:
The Potential Link Between HCMV Infection and Essential Hypertension
It has been reported that mouse cytomegalovirus infection alone can elevate the blood
pressure in mice. Since HCMV has uniquely evolved with its human host, with little genetic
similarity to the animal CMV counterparts, and it only replicates in human, an
epidemiological study is required to define the relevance of HCMV infection and expression
of hcmv-miRNA-UL112 to the pathogenesis of essential hypertension.
The investigators found that hcmv-miR-UL112, a human cytomegalovirus (HCMV)-encoded miRNA,
was highly expressed in the hypertensive patients. Among the top miRNA target predictions,
the investigators demonstrate that IRF-1 is a direct target gene of hcmv-miR-UL112, along
with MICB that has been previously reported. Both IRF-1 and MICB play critical roles in
immuno/inflammatory and anti-infection response. Thus, the investigators speculated that
IRF-1 and MICB repression by hcmv-miR-UL112 could be considered a unifying mechanism that
evades the host response at several levels: antiviral, inflammatory, and immune. In
addition, there is an increasing evidence that IRF-1 may be important in apoptosis,
angiogenesis, neointima formation and the pathogenesis of vascular diseases. IRF-1 can
up-regulate angiotensin II type 2 receptor (AGTR2) that exerts antiproliferative and
proapoptotic actions and affects regulation of blood pressure. It has been reported that the
targeted disruption of the mouse AGTR2 gene resulted in a significant increase in blood
pressure and increased sensitivity to angiotensin II. The nitric oxide synthase expression
and NO synthesis in macrophages and distinct cardiomyocytes are induced and controlled by
IRF-1 in response to inflammation, important steps in vascular biology that may improve
endothelial function and inhibit smooth muscle cell migration, and a key pathophysiological
event in hypertension. Collectively, these reports support a strong relationship between
IRF-1 regulation and hypertension, indicating a potential role of hcmv-miR-UL112 and HCMV
infection in the pathogenesis of hypertension.Thus, the investigators want to investigate
the potential link between HCMV infection and essential hypertension.
n/a
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