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HCC clinical trials

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NCT ID: NCT06253364 Completed - Recurrence Clinical Trials

VETC is an Effective Marker for Postoperative Adjuvant Immunotherapy

Start date: January 1, 2019
Phase:
Study type: Observational

Vessels that encapsulate tumor clusters (VETC) is an invasive metastatic factor in HCC independent of the epithelial mesenchyme transition (EMT), and VETC-positive patients have a higher rate of postoperative recurrence. However, it is not clear how the surgical prognosis of VETC-positive patients can be improved.

NCT ID: NCT06008548 Completed - HCC Clinical Trials

A New Conception About Individualized Treatment Allocation for HCC

PTA4HCC
Start date: January 1, 2010
Phase:
Study type: Observational

The current guidelines on hepatocellular carcinoma (HCC) aimed to build effective prognostic stratification strategies to guide therapeutic allocation; however, the current guidelines did not consider the simultaneous comparison of distinct therapies in similar populations. Here, the investigators aimed to develop and validate a new, integrated prognostic scheme for HCC patients using artificial intelligence (AI) to simulate the survival outcomes of patients allocated to different treatments.

NCT ID: NCT05471674 Completed - Clinical trials for Hepatocellular Carcinoma

Neoadjuvant Anti-PD1 in HCC

Start date: July 3, 2020
Phase: Phase 2
Study type: Interventional

This is a phase 2, single-arm trial designed to assess the clinical benefit of treatment with nivolumab administered in patients with untreated, borderline resectable HCC.

NCT ID: NCT05450874 Completed - HCC Clinical Trials

A Novel MSE Score to Predict rHCC Patients

Start date: February 1, 2010
Phase:
Study type: Observational

Develop and validate a novel scoring system based on pathological factors to predict the postoperative survival of patients with rHCC.Patients with rHCC who underwent hepatectomy were recruited from two hospitals.Exploring whether this scoring system is related to prognosis

NCT ID: NCT05402644 Completed - Portal Hypertension Clinical Trials

Hepatectomy for Early-stage HCC Patients With CSPH

Start date: December 1, 2009
Phase:
Study type: Observational

Clinically significant portal hypertension (CSPH) can affect the surgical prognosis of early-stage (BCLC stage A) HCC. An additional stage, such as the BCLC stage A-B, can be considered.

NCT ID: NCT05202184 Completed - HCC Clinical Trials

Non Transplantable Recurrence After Percutaneous Thermal Ablation of HCC

Start date: January 1, 2015
Phase:
Study type: Observational

Percutaneous thermal ablation (PTA), resection and liver transplantation (LT) are the standard curative options for hepatocellular carcinoma (HCC). LT yields the best long-term outcomes but is limited by graft shortage. Thus, patients with ≤3cm HCC are mainly treated by PTA although recurrence is frequent and may occur outside transplant criteria. However, data on non transplantable recurrence (NTR) following PTA are lacking. Therefore, the investigators investigated the incidence and predictors of NTR among transplantable patients with ≤3cm HCC(s) treated by PTA, in order to stratify them according to their NTR risk and to improve treatment allocation.

NCT ID: NCT04542837 Completed - HCC Clinical Trials

The Study of KN046 in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma

Start date: September 11, 2020
Phase: Phase 2
Study type: Interventional

This ia a single-arm, not-randomized, open-label phase II study. The purpose of this study is to evaluate the safety and efficacy of KN046 (PD-L1 /CTLA-4 Bispecific antibody) combined with Lenvatinib(TKI) for the treatment of advanced hepatocellular carcinoma.

NCT ID: NCT04530240 Completed - HCC Clinical Trials

Equity and Efficacy of Allocation Priority for Liver Transplantation Patients With MELD≥30 in Italy

Start date: August 1, 2010
Phase:
Study type: Observational

In Italy, since August 2014, liver transplantation (LT) candidates with MELD≥30 receive a priority allocation consenting them to access in an organ sharing macroarea. The primary intent of this policy is to minimize the higher risk of waiting list dropout observed in these patients. Another objective of this allocation strategy is to reduce the waiting time, thus performing the LT in better clinical conditions. This multicentre retrospective national study aims to evaluate several parameters of efficacy and equity, such as waiting time in the list, dropout rate, and graft survival, in two eras of enlisted patients, before and after the introduction of the macroarea sharing policy in Italy. With the intent to minimize the presence of possible selection biases, the two groups were matched trough Propensity Score Matching (PSM).

NCT ID: NCT04326491 Completed - Cirrhosis, Liver Clinical Trials

The Utility of Breath Biopsy as a Screening Tool for HCC

BrtH-C
Start date: June 20, 2021
Phase:
Study type: Observational

The aim of this pilot study is to examine whether there is a discriminating ability of the breath sample analysis to capture biomarkers specific to the HCC in the breath of affected individuals. If positive, our research could open up a new horizon for cost-effective and feasible screening tools.

NCT ID: NCT04173520 Completed - HCC Clinical Trials

ELRIAH Score: A Simple Score for HCC Risk Stratification in CHC Patients With Cirrhosis or Advanced Liver Fibrosis Who Achieved SVR Following DAA Therapy

Start date: January 2015
Phase:
Study type: Observational

aimed to develop a scoring system to assess risk of developing HCC in a large cohort of chronic hepatitis C (CHC) patients with advanced hepatic fibrosis (F3) or cirrhosis (F4) with sustained virological response (SVR) after receiving direct acting antivirals (DAAs).