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Graft Failure clinical trials

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NCT ID: NCT03657199 Completed - Clinical trials for Coronary Artery Disease

Early Silent Graft Failure in Off-pump Coronary Artery Bypass Grafting: A Computed Tomography Analysis

Start date: January 1, 2017
Phase:
Study type: Observational

Aortocoronary bypass surgery is one of the most common operations in the western world. The goal of the surgeon is to perform a complete revascularization of the coronary arteries with the best, available bypass material. Aortocoronary bypass surgery can be performed with (on-pump) or without (off-pump) the heart lung machine. If the operation is performed without the heart lung machine, the heart is continuously beating while the surgeon sews the bypass to the diseased coronary artery. In randomized trials, the benefits of the off-pump technique in the hands of experienced surgeons in terms of shorter operating times, less transfusions and less pulmonary and renal complications were proven. A criticism of the off-pump technique is the reduced number of distal anastomoses, which means that fewer coronary arteries may be connected with bypass grafts because of the technically sophisticated situation. A worse quality of the connection (anastomosis) between coronary artery and bypass is often discussed, leading to a bypass occlusion already in the early stage after surgery resulting in more re-interventions on the coronary vessels. So-called silent bypass failure without clinical correlation has been examined in three relevant studies including both, the on- and the off-pump technique, with inhomogenous results. In addition to the technique, other parameters such as the degree of narrowing (stenosis) of the diseased coronary artery and collateralization of a closed coronary artery may play a role in early occlusion. All bypass patients after off-pump surgery receive routinely a computed tomographic examination of the heart. With this method, silent bypass occlusions without clinical correlation, i.e. cardiac infarction, elevated cardiac laboratory parameters or ECG changes, can be detected easily. In case of an occlusion of a relevant bypass, an intervention before discharge can be planned and performed. We would like to investigate the occlusion rate of this retrospective patient cohort after off-pump surgery and the potential risk factors, that may influence on early graft failure. We hypothesize, that early graft failure depends not only on the choice of the graft material, but also on the local grade of coronary stenosis, the collateralisation of occluded coronary vessels and the intraoperative flow results, as well as on the region of the target vessel.

NCT ID: NCT03373227 Active, not recruiting - Graft Failure Clinical Trials

Phase II Study Evaluating the Efficacy of Tacrolimus Extended Release Tablets to Twice Daily Tacrolimus Dosing Regimen

Veloxis
Start date: December 4, 2017
Phase: Phase 2
Study type: Interventional

This phase II, single-center, open-label study will evaluate the comparable efficacy of tacrolimus extended release tablets (Envarsus®) to the standard of care (SOC) twice daily tacrolimus (Prograf®) dosing regimen post-cardiac transplantation.

NCT ID: NCT03272854 Active, not recruiting - Diabetes Clinical Trials

TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study

TxL-IRI
Start date: August 2001
Phase: N/A
Study type: Observational [Patient Registry]

Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, the investigators hypothesize that in renal transplant recipient, amongst others overweight, obesity, chronic use of immunosuppressive drugs and impaired renal function contribute to insulin resistance and chronic low-grade inflammation, which pose the renal transplant recipients at increased risk for cardiovascular disease, decline of function of the transplanted kidney and other complications, including post-transplant diabetes. This study is a biobank and cohort study which investigates this hypothesis.

NCT ID: NCT03019809 Recruiting - Clinical trials for Hematopoietic Stem Cell Transplantation

A Trial of Plerixafor/G-CSF as Additional Agents for Conditioning Before TCR Alpha/Beta Depleted HSCT in WAS Patients

Start date: June 2016
Phase: Phase 2
Study type: Interventional

Treatment Study to assess of safety and efficiency of conditioning with Plerixafor and G-CSF as additional agents for prevention of graft failure after transplantation with TCR alpha/beta grafts depletion in patient with Wiskott-Aldrich syndrome.

NCT ID: NCT02558452 Not yet recruiting - Quality of Life Clinical Trials

European Transplant Registry of Senior Renal Transplant Recipients on Advagraf

SENIOR
Start date: December 2016
Phase: N/A
Study type: Observational [Patient Registry]

SENIOR transplant Registry European transplant registry of senior renal transplant recipients (above the age of 65 years) receiving initial immunosuppression with tacrolimus once daily, mycophenolate and steroids to investigate long term outcomes on an observational basis.

NCT ID: NCT02556879 Active, not recruiting - Clinical trials for Liver Transplantation

Immunization Anti HLA in the Liver Transplant Recipients (DSATH)

DSATH
Start date: March 9, 2016
Phase: N/A
Study type: Interventional

Anti HLA alloimmunization against the donor evaluated by the detection of anti-donor specific antibodies (DSA) is an underestimated factor in liver transplantation and may contribute to dysfunction and graft loss , especially among candidates for retransplantation, that have major immunization. This study will analyzed immunization markers at the time of liver retransplantation and systematically in patients follow-up. This will allow to characterize the histological lesions due to humoral immunization, to establish further investigations and to adapt early immunosuppressive therapy.

NCT ID: NCT02061462 Recruiting - Graft Failure Clinical Trials

EVLP to Evaluate the Eligibility for Transplantation of DCD-Lungs

EVLP-DCD
Start date: October 2014
Phase: Phase 1
Study type: Interventional

The procurement of organs from donors after cardiocirculatory death (DCD) is an accepted strategy to increase organ supply.

NCT ID: NCT02026934 No longer available - Clinical trials for Delayed Graft Function

CliniMACS® CD34+ Reagent System for Expanded Access Use

Start date: March 2013
Phase: N/A
Study type: Expanded Access

CliniMACs is an investigational device used to select and enrich stem cells. The device will select the stem cells with CD34+ protein. The participant will be infused with the CD34+ selected cells in the hopes that it will help the participant engraft. Engraftment is when transplanted stem cells resume production of healthy blood cells.

NCT ID: NCT01970605 Completed - Aneurysm Clinical Trials

Silver Graft All Comers Registry

Start date: October 2013
Phase:
Study type: Observational

This web based e-Registry will be international, multi-center and prospective. Silver Graft e-Registry to assess the long term clinical benefit of Silver Graft in an unselected patient population

NCT ID: NCT01967953 Completed - Brain Death Clinical Trials

Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation

EVLP_MI
Start date: January 2011
Phase: Phase 1
Study type: Interventional

The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.