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Gingivitis clinical trials

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NCT ID: NCT06307041 Completed - Gingivitis Clinical Trials

Effects of 0.2% Hyaluronic Acid Gel-Impregnated Dental Flosses on Clinical Gingival Parameters

Start date: April 3, 2023
Phase: N/A
Study type: Interventional

This study aimed to evaluate the effects of 0.2% HA-impregnated dental flosses on the clinical periodontal parameters of patients with gingivitis.

NCT ID: NCT06305546 Completed - Gingivitis Clinical Trials

Comparisons Of Different Antiplaque Agents On Gingivitis In Orthodontic Patients

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

Fixed orthodontic treatment affects the periodontium by allowing plaque accumulation on teeth if the oral ecosystem is unfavorable which initially causes gingivitis to progress into periodontitis, and later enamel demineralization occurs. Yáñez-Vico et al observed that regular modifications per checkups were painful and unpleasant for the patient thus the patients undergoing fixed orthodontic treatments compromised their oral hygiene. This creates plaque retention sites which can lead to developing white spot lesions, caries, and periodontitis

NCT ID: NCT06300866 Completed - Gingivitis Clinical Trials

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

Start date: August 18, 2020
Phase: Phase 3
Study type: Interventional

The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of product use.

NCT ID: NCT06293911 Enrolling by invitation - Down Syndrome Clinical Trials

Clinical Comparison of a Postbiotic-gel With Placebo Gel for Gingival Inflammation in Patients With Down Syndrome

Start date: March 15, 2024
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the efficacy of home treatment with a postbiotic-based gel for the management of periodontal inflammation in patients with Down syndrome. Patients will be enrolled at the S.C. Odontostomatologia dell'Azienda Ospedaliera "Ordine Mauriziano di Torino", Turin, Italy. After the collection of the periodontal clinical indexes (BoP%, PCR%, dental mobility, mMGI, compliance and satisfaction questionnaire), patients will undergo a professional mechanical debridement with ultrasonic instruments and glycine powders. Then, they will be randomly divided into two groups according to the home treatment: - in the Trial group Biorepair Plus Parodontgel Intensive (containing microRepair®, hyaluronic acid, Lactobacillus Ferment and Aloe Barbadensis Leaf Juice Powder) will be used once a day for all the duration of the study - in the Control group, a placebo gel without (active ingredients) will be used once a day for all the duration of the study. Indexes will be re-evaluated after 1 (T1), 3 (T2) and 6 months. The professional mechanical debridement will be performed again at T3 timepoint.

NCT ID: NCT06291350 Not yet recruiting - Clinical trials for Pemphigoid, Benign Mucous Membrane

Peridontal and Intestinal Microbiota in Patients With Gingival Scarring Pemphigoid

MICROPC
Start date: March 15, 2024
Phase:
Study type: Observational

Patients suffering from Mucous Membrane Pemphigoid with desquamative gingivitis (MMPg) generally present a more degraded periodontal condition compared with controls. Bullous disease could represent a risk factor for plaque-induced periodontal disease, and vice versa. Indeed, the dysbiotic periodontal microbiota could aggravate the gingival damage specific to MMP, either directly by activating inflammatory pathways, or indirectly by degrading cellular and matrix components. On the other hand, areas of erosive gingiva generated by the autoimmune process could increase the virulent power of periodontal pathobionts, by representing accessible, nutrient-rich connective surfaces. Moreover, in recent years, bacterial studies based on a high-throughput metagenomic approach have suggested the existence of a relationship between the oral and intestinal microbiota in patients with degraded periodontal conditions and suffering from autoimmune inflammatory diseases (inflammatory bowel disease, acute graft-versus-host disease). This relationship can also be envisaged in MMPg patients who meet the conditions that allow this type of pathological process to occur: autoimmune disease; disruption of the gingival epithelial barrier in erosive gingival areas (increasing the risk of antigen exposure); large amounts of thick plaque; degraded periodontal condition with the presence of numerous periodontal pockets from which periodontopathogenic bacteria can translocate intra-tissularly and cause distant adverse consequences. The main aim of this observational, multicentre, case-control, matched study is to compare the composition of the periodontal microbiota between MMPg patients and control patients (arm 2 and arm 3). The secondary objectives are to compare the composition of periodontal and intestinal microbiota in cases and control patients (arm 2 and arm 3), to compare periodontal microbiota composition in cases and control patients (arm 2) according to periodontitis severity, and to compare gut microbiota composition between cases and control patients (arm 2 and arm3). To date, no such study exists.

NCT ID: NCT06291129 Active, not recruiting - Diabetes Clinical Trials

Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents

Start date: October 30, 2022
Phase: N/A
Study type: Interventional

Introduction: This study aims to evaluate the gingivitis, periodontal profile and malocclusion in children and adolescents with diabetes. Methods: The sample consisted of 36 children, who were distributed into two groups: DM; n=18 and NDM; n=18. Periodontal parameters considered were plaque Index (PI), gingival Index (GI), probing depth of pocket (PPD), gingival recession (GR) and clinical attachment level (CAL). Gingival biotype clinical parameters: Gingival transparency to probing, Height of keratinized mucosa and Gingival thickness on permanent incisors and molars. Malocclusion were evaluated by the Dental Aesthetic Index (DAI) and the Angle's Classification. The statistical analyses were Shapiro Wilk test and T test.

NCT ID: NCT06250764 Completed - Obesity Clinical Trials

Asprosin, Adropin, Irisin Levels in Periodontitis

Start date: February 12, 2020
Phase:
Study type: Observational [Patient Registry]

The recently discovered association of the hormones 'asprosin, adropin and irisin' with obesity and metabolic status, as well as the fact that periodontal diseases are affected by obesity and nutrition bilaterally, have led us to investigate the relationship between selected target markers and periodontal disease. The primary aim and main objective of this study is to increase the knowledge and to direct future researches as a result of the lack of adequate research in the past and the very limited investigations with these hormones in dentistry and periodontology. Our study was conducted on 122 patients who applied to Adıyaman University Faculty of Dentistry and were referred to the Department of Periodontology for routine periodontal controls. Participants' gender, age, height, weight, BMI, education level, tooth brushing and flossing habits as well as clinical parameters PI, GI, SCD, CAS and SDI were noted. Participants were divided into 4 groups as healthy, gingivitis, initial periodontitis and advanced periodontitis and grouped according to the current periodontal classification of 2017. DOS was collected from the groups for examination and 'asprosin, adropin and irisin' values in the samples were evaluated by ELISA test.

NCT ID: NCT06244303 Active, not recruiting - Gingivitis Clinical Trials

Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.

Start date: January 22, 2024
Phase: Phase 3
Study type: Interventional

Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided. Subjects will return to the dental office for evaluation after 1-, 3-, 6-, and 12-weeks of unsupervised product use at home. All subjects will be followed for adverse events throughout the study

NCT ID: NCT06240481 Not yet recruiting - Gingivitis Clinical Trials

Clinical Research Study to Assess the Efficacy of Two Brushing Regimens

Start date: February 12, 2024
Phase: Phase 3
Study type: Interventional

The objective of this twelve-week clinical research study is to assess the efficacy of two brushing regimens: 1) toothpaste with mouthwash containing sodium fluoride/zinc and manual toothbrush as compared to 2) regular fluoride toothpaste and manual toothbrush in the reduction of dental plaque and aid of gum problems.

NCT ID: NCT06240247 Recruiting - Gingivitis Clinical Trials

Associations Between Birth Order, Sibship Size and Periodontal Disease

Start date: January 31, 2024
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about the relationship between sibship size, birth order, gingival health, and oral health habits in systematical healthy participants. The main questions it aims to answer are: question 1: Is there any association between birth order and gingival health? question 2: Is there any association between birth order and oral health habits? question 3: Is there any association between birth order, sibship size, childhood socioeconomic factors, perinatal characteristics, and Oral Health-Related Quality of Life and Periodontal Disease? Participants will simply have their routine periodontal examination, fill out the provided questionnaire, and continue their routine periodontal treatment.