Accuracy of CNAP PPV Under General Anaesthesia

General Anaesthesia Clinical Trial

Official title:

Comparison of the Non-invasive CNAP Pulse Pressure Variation With the Invasive Gold Standard

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02166580
• Other study ID #: CNAP 2012_2
• Status: Completed
• Phase: N/A
• First received: December 4, 2012
• Last updated: June 3, 2017
• Start date: January 2014
• Est. completion date: July 2015

Study information

• Verified date: June 2017
• Source: University of Schleswig-Holstein
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor.

Hypothesis: Noninvasive CNAP PPV predicts fluid responsiveness. A grey zone for the prediction of fluid responsiveness will be defined.

Description:

Accuracy of PPV measured by two devices,PICCO and CNAP, is compared with the manually calculated PPV from the arterial line waveform. Established tests like passive leg raising and end-expiratory occlusion are used for prediction of fluid responsiveness. Intraoperative events like volume challenge are monitored.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: July 2015
• Est. primary completion date: July 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• major surgery

• need for invasive arterial measurements

Exclusion Criteria:

• age under 18

• cardiac dysrhythmia

• vascular pathology at punction site

Related Conditions & MeSH terms

• General Anaesthesia

Locations

Country	Name	City	State
Germany	University Hospital, Schleswig-Holstein. Departement of Anaesthesiology and Intensive Care Medicine	Kiel

Sponsors (1)

Lead Sponsor	Collaborator
University of Schleswig-Holstein

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cardiac output	Improvement of cardiac output dependent on PPV before volume challenge	1, 2, 5, 10, 15 and 20 minutes after volume challange and