Frail Elderly Syndrome Clinical Trial
Official title:
The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome
This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital. The investigators will conduct frailty assessment (FRAIL scale, CFS, SPPB), comorbidities, functional status (Barthel index, ADL, IADL), nutritional risk (MNA-SF), and then observe the clinical outcomes of elderly ACS participants with frailty. Then, the investigators will follow-up these participants separately in 1,3,6 and 12months, the anticipate follow-up time is 1 year. According to the follow-up results, investigators will evaluate the impact of frailty and other senile syndromes on the short-term and long-term prognosis of ACS, and develop a scoring system for the prognosis evaluation of elderly ACS participants.
Status | Recruiting |
Enrollment | 1000 |
Est. completion date | December 2021 |
Est. primary completion date | December 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - Elderly participants over 65 - Clinical diagnosis of acute coronary syndrome - Must be able to follow-up - Sign in the informed consent Exclusion Criteria: - Myocardial infarction caused by other acute disease - Mental disorders who cannot cooperate to complete the assessment - Severe liver dysfunction, kidney disease (CKD 5), end-stage malignant tumor - Totally disabled and bedridden |
Country | Name | City | State |
---|---|---|---|
China | Beijing Friendship hospital | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Beijing Friendship Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Death | All-cause death and cardiac death events | During hospitalization, assessed up to 2 months | |
Primary | Major Adverse Cardiac and Cerebrovascular events | Major Adverse Cardiac and Cerebrovascular events including heart failure, cardiac shock, malignant arrhythmia, myocardial infarction, revascularization, and cerebral infarction | During hospitalization, assessed up to 2 months | |
Primary | Death | All-cause death and cardiac death events | 1 year | |
Primary | Major Adverse Cardiac and Cerebrovascular events | Major Adverse Cardiac and Cerebrovascular events including heart failure, cardiac shock, malignant arrhythmia, myocardial infarction, revascularization, and cerebral infarction | 1 year |
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