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Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults — AFFIRM-LITE  

Frail Elderly Syndrome Clinical Trial

Official title:
AFFIRM-LITE: A Phase 2 Randomized, Placebo-Controlled Study of Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults

Clinical Trial Summary

This is a pilot study to test the efficacy of the anti-inflammatory drug (Fisetin) in reducing inflammatory factors in blood in elderly adults and to test the efficacy of the drug (Fisetin) in reducing frailty and markers of inflammation, insulin resistance, and bone resorption in elderly adults.

Clinical Trial Description

To the researchers' knowledge, there are no published studies utilizing Fisetin in alteration of frailty markers. Several studies involve use of Fisetin for its anti-oxidative and anti-apoptotic effects in animal models. Fisetin may reduce oxidative stress, alleviate hyperglycemia, and improve kidney function. No one has evaluated the biologic markers of inflammation and frailty in older adults. The researchers plan to evaluate markers of frailty and markers of inflammation, insulin resistance, and bone resorption while maintaining bone formation in older adults. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03675724
Study type Interventional
Source Mayo Clinic
Contact
Status Enrolling by invitation
Phase Phase 2
Start date November 15, 2018
Completion date October 2024
View Details
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