Clinical Trials Logo
  1. Home
  2. Frail Elderly Syndrome
  3. NCT03675724

Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults — AFFIRM-LITE  

Frail Elderly Syndrome Clinical Trial

Official title:
AFFIRM-LITE: A Phase 2 Randomized, Placebo-Controlled Study of Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults

Clinical Trial Summary

This is a pilot study to test the efficacy of the anti-inflammatory drug (Fisetin) in reducing inflammatory factors in blood in elderly adults and to test the efficacy of the drug (Fisetin) in reducing frailty and markers of inflammation, insulin resistance, and bone resorption in elderly adults.

Clinical Trial Description

To the researchers' knowledge, there are no published studies utilizing Fisetin in alteration of frailty markers. Several studies involve use of Fisetin for its anti-oxidative and anti-apoptotic effects in animal models. Fisetin may reduce oxidative stress, alleviate hyperglycemia, and improve kidney function. No one has evaluated the biologic markers of inflammation and frailty in older adults. The researchers plan to evaluate markers of frailty and markers of inflammation, insulin resistance, and bone resorption while maintaining bone formation in older adults. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03675724
Study type Interventional
Source Mayo Clinic
Contact
Status Enrolling by invitation
Phase Phase 2
Start date November 15, 2018
Completion date October 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04792983 - Cognition and the Immunology of Postoperative Outcomes
Completed NCT03271112 - Frailty Prevention in Elders From Reunion Island N/A
Recruiting NCT03141866 - Seated Physical Activity in Ageing N/A
Completed NCT03180606 - Enhanced Primary Care for Elderly
Recruiting NCT05940779 - Relationship Between the Risk of Falls and Frailty, and the Effect of a Physical Exercise Program on These Conditions in the Elderly: a Randomized Crossover Clinical Trial. N/A
Active, not recruiting NCT05961319 - Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
Recruiting NCT04518423 - Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
Completed NCT03883425 - Frailty and Complexity Among Home Service Recipients
Recruiting NCT03657940 - Impact of a Multicomponent Exercise Program on Functional Capacity in Frail Aged Participants With Cognitive Decline N/A
Withdrawn NCT03176030 - Fortified Foods in Older Inpatients
Completed NCT03724461 - Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly N/A
Completed NCT04615533 - Validity Reliability of FrailBESTest in Older Adults
Recruiting NCT04238494 - Muscle Multi-parametric NMR Imaging Development in Aged People With Sarcopenia or Frailty Syndrome; CLINical Study N/A
Active, not recruiting NCT06079762 - AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program N/A
Not yet recruiting NCT06019390 - eHealth for Screening Health Risks in Home-Based Older Adults: A Prospective Study N/A
Recruiting NCT03534765 - Frailty and Sarcopenia Outcomes in Emergency General Surgery
Active, not recruiting NCT03721471 - Outcome of Very Old Patients Admitted for Elective Major Surgery, the Effect of Frailty
Completed NCT03689322 - Effects of WBV Associated With IMT on Inflammatory Markers, Body Composition, Muscle Strength and Thickness N/A
Completed NCT03688932 - Effects of WBV Associated With IMT on Functionality N/A
Recruiting NCT03068299 - Effects of Music and Dance on Cognition, Frailty, and Burden in Elderly Caregivers Living in Rural Communities N/A