View clinical trials related to Fibromyalgia.
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The goal of this observational study is to test for behavioural and neurophysiological biomarkers in fibromyalgia patients. The main questions it aims to answer are: - Is there a measurable decline in working memory? - Could these measures help in fibromyalgia differential diagnosis? Participants will: - perform Color Comparison tasks - perform n-back tasks
The goal of this observational study is to learn about interoception and proprioception in patients with fibromyalgia. The main questions it aims to answer are: - Is there a significant difference in interoception between patients with fibromyalgia and healthy controls? - Is there a significant difference in proprioception between patients with fibromyalgia and healthy controls? The participants will perform: - The respiratory occlusion discrimination task - A postural control task where the effect of muscle vibration on center of gravity displacement is examined - The head repositioning accuracy task The participants will also fill out different questionnaires. Researchers will compare healthy controls to see if there is a significant difference.
The goal of this observational study is to learn about interoception in patients with stress related syndromes (overstrain, burnout; SRS) and functional disorder (fibromyalgia/ chronic fatigue syndrome; FD). The main questions it aims to answer are: - Is there a significant difference in interoception between patients with SRS and healthy controls? - Is there a significant difference in interoception between patients with FD and healthy controls? - Is there a significant difference in interoception between patients with SRS and FD? The participants will perform the respiratory occlusion discrimination task and have to fill out some questionnaires. Researchers will compare healthy controls to see if there is a significant difference.
There is a growing interest in the potential benefits of attentional bias modification (ABM) training in chronic pain patients. However, studies examining the effectiveness of ABM programs in fibromyalgia patients have demonstrated inconclusive effects on both behavioral indices and clinical symptoms. Underlying neural dynamics of ABM effects could yield additional insights but remain yet unexplored. Current study, therefore, aimed investigating the effects of ABM training on known neural indicators of attentional bias to pain using electroencephalography (EEG). The goal of this clinical trial is to test the effects of ABM training on known neural indicators of attentional bias to pain using electroencephalography (EEG) in fibromyalgia patients The main question[s] it aims to answer are: - Are fibromyalgia patients sensitive to ABM procedures? - What are the neural indices associated with ABM procedures? - Do ABM procedures transfer of effects on the clinical symptomatology in fibromyalgia patients? Participants will performes five sessions consisting of a modified dot-probe task in which patients were trained to avoid facial pain expressions, whereas in the control group participants will performes five sessions consisting of a standard dot-probe task. Potential ABM training effects will be evaluated by comparing a single pre- and post-treatment session, in which event-related potentials (ERPs) will be recorded in response to three experimental tasks (standard dot-probe, RIR, and visual tasks). Furthermore, patients will fill a series of self-report questionnaires assessing anxiety, depression, pain-related worrying, fear of pain, fatigue and pain status. Researchers will compare two fibromyalgia patients groups that will enrolled and randomly assigned to an ABM training in order to see attentional improvements in the training fibromyalgia group.
This study will be conducted to investigate High-intensity laser therapy improves pain, health status and quality of life in women with fibromyalgia
Fibromyalgia (FM) is a syndrome characterized by generalized musculoskeletal pain, fatigue, non-restorative sleep, cognitive alterations, depressive and neurovegetative symptoms. Conventional pharmacological therapies are known to produce responses with little clinical impact in more than 50% of patients. Functional alterations of the motor cortex and its connections with subcortical structures have also been demonstrated in FM. Based on the above, the objective of this research is to identify subgroups of patients with greater potential for response to treatment with a view to advancing diagnosis and treatment. In this study, the therapeutic target will be transcranial direct current stimulation (tDCS) according to the potential of responsiveness to the placebo effect, with the precise location of the stimulation area by a neuronavigation system, with the objective of counter-regulating the processes dysfunctional factors responsible for triggering and maintaining FM symptoms. Therefore, this clinical trial aims to compare the effectiveness of anodic tDCS applied in the left dorsolateral prefrontal cortex (DLPFC) compared to sham tDCS in FM, according to susceptibility to the placebo effect and serum endorphin levels.
The main purpose of the project is to evaluate the safety and efficacy of low dose metformin for improving symptoms associated with fibromyalgia syndrome (FMS) via modulating neuroinflammatory pathways. The investigators hypothesize that FMS patients in the low-dose metformin conditions will show greater improvement in FMS symptoms than those who are in the placebo group. Further, the investigators hypothesize that metformin will increase phosphorylated AMPK in peripheral immune cells of FMS patients and will decrease the transcription of mTORC1, NLRP3 inflammasome, and nociceptive cytokines interleukin 1beta and interleukin 18.
The study aims to determine the effect of connective tissue massage and taping applications on the pain and depression complaints of fibromyalgia patients and to compare their impact on quality of life.
The main aim of this study is to find out whether applying both pain neuroscience education (PNE) and motor imagery-based exercise protocol (MIEP) will primarily reduce the pain of fibromyalgia. These therapies could show an evidence of improvement in fibromyalgia patients. However, there are no studies evaluating their effectiveness in combination. Secondary outcomes: To assess motor imagery ability of PNE in fibromyalgia patients To assess motor imagery ability of MIEP in fibromyalgia patients To evaluate the motor imagery ability of PNE+MIEP combined in fibromyalgia patients To evaluate pain beliefs of PNE in fibromyalgia patients To assess the pain beliefs of MIEP in fibromyalgia patients Combined PNE+MIEP to assess pain beliefs in fibromyalgia patients. To assess fear of movement in fibromyalgia patients of PNE To assess fear of movement in fibromyalgia patients of MIEP Combined PNE+MIEP to assess fear of movement in patients with fibromyalgia PNE to assess anxiety, depression, cognitive and mood in patients with fibromyalgia. To assess anxiety, depression, cognitive and mood in patients with fibromyalgia MIEP To evaluate anxiety, depression, cognitive and mood in patients with fibromyalgia together with PNE+MIEP PNE to assess self-esteem and body awareness in fibromyalgia patients. To assess self-esteem and body awareness in fibromyalgia patients of MIEP Combined PNE+MIEP to assess self-esteem and body awareness in fibromyalgia patients.