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Clinical Trial Summary

The goal is to investigate whether endometrial flushing with Lipiodol enhances fertility. Therefore, anatomo-pathological, histochemical and transcriptional changes of the endometrium after Lipiodol bathing in a general population of healthy volunteers will be determined.


Clinical Trial Description

A single-centre, cross-over, open-label trial will be performed. Healthy volunteers, fulfilling the inclusion/exclusion criteria, will be asked to do blood samples and ultrasounds for the detection of the LH (luteinizing hormone) surge in a natural cycle. The intervention group will undergo endometrial flushing with Lipiodol between day 6 and 8 of the cycle, while the control group between day 6 and 8 of the cycle will have a mock catheter introduction without any Lipiodol flush. An endometrial biopsy will be performed 7 days after the LH peak in all the participants. Furthermore, all the participants will undergo one cycle with flushing and one cycle with introduction of a mock catheter but without flushing with any medication. The wash-out period between the 2 biopsies will be 3 months. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03542331
Study type Interventional
Source Universitair Ziekenhuis Brussel
Contact Christophe Blockeel, PhD
Phone +3224776699
Email christophe.blockeel@uzbrussel.be
Status Recruiting
Phase Phase 3
Start date March 1, 2018
Completion date January 2020

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