Association of Processing Speed Dysfunction and Brain Functional Abnormality in ECTS

Epilepsy, Rolandic Clinical Trial

Official title: Association of Processing Speed Dysfunction and Brain Functional Abnormality in Childhood Epilepsy With Centrotemporal Spikes

Status Completed

Clinical Trial Summary

Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children. Language impairment has been widely investigated in patients with ECTS, but little is known about the cognitive dysfunction of processing speed and its neuroimaging mechanism.

Clinical Trial Description

OBJECTIVE To investigate the processing speed dysfunction in patients with ECTS, and the associated brain functional abnormality using functional magnetic resonance imaging (fMRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). DESIGN, SETTING, AND PARTICIPANTS This study prospectively enrolled ECTS patients (n = 28) from June 2019 and June 2021. Twenty age- and gender- matched healthy children and another twenty children with extracranial tumors were enrolled as controls. Patients with ECTS and healthy controls underwent neuropsychological testing and fMRI examination. In addition, ECTS patients and children with extracranial tumors underwent 18F-FDG PET examination. ;

Related Conditions & MeSH terms

• Epilepsy
• Epilepsy, Rolandic

• NCT number: NCT04954729
• Study type: Observational
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Status: Completed
• Start date: June 1, 2019
• Completion date: June 30, 2021