Clinical Trials Logo
  1. Home
  2. Endothelial Function
  3. NCT01610401

The Metformin-FMD Trial — MetFMD  

Endothelial Function Clinical Trial

Official title:
Can Metformin Prevent Endothelial Ischemia and Reperfusion Injury? The Metformin-FMD Trial

Clinical Trial Summary

In acute myocardial infarction early restoration of coronary blood flow is the most effective strategy to limit infarct-size. Paradoxically, reperfusion itself also aggravates myocardial injury and contributes to final infarct size, a process termed 'reperfusion injury'. Ischemia and reperfusion (IR)-induced endothelial dysfunction seems to play a pivotal role in this process, resulting in vasoconstriction and reduced blood flow to the already ischemic tissue. Recently, it has been shown that the glucose-lowering drug metformin is able to limit IR-injury in murine models of myocardial infarction, probably by increased formation of the endogenous nucleoside adenosine. In the current research proposal, the investigators aim to translate this finding to the human in vivo situation, using flow-mediated dilation (FMD) of the brachial artery as a well-validated model of (endothelial) IR-injury.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01610401
Study type Interventional
Source Radboud University
Contact
Status Completed
Phase Phase 4
Start date May 2012
Completion date January 2013
View Details
See also
  Status Clinical Trial Phase
Completed NCT03301402 - Air Purifier to Improve Endothelial Function and Carotid Intima Thickness N/A
Recruiting NCT02500329 - Effect of Gemigliptin or Acarbose on Endothelial Function in Type 2 DM Patients Phase 4
Completed NCT01947790 - Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease Phase 4
Completed NCT01028599 - Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients N/A
Completed NCT00575120 - Endothelial Function Assessed With BOLD-MRI N/A
Active, not recruiting NCT05451641 - Blood Flow Restriction Resistance Training Intervention on Vascular Function N/A
Completed NCT01713374 - Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System N/A
Completed NCT03651713 - Hyperglycemia, Exercise, and Endothelial Function N/A
Completed NCT00844714 - Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy N/A
Completed NCT00967252 - Impact of Chronic Statin Use During Surgery on Inflammation and Infection Rates N/A
Completed NCT01256957 - Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health N/A
Completed NCT00845013 - Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension
Completed NCT00728221 - Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation Phase 2
Completed NCT00534651 - Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease Phase 4
Recruiting NCT04689477 - Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
Completed NCT01829542 - Dose-dependent Effects of Blueberry Polyphenols on Endothelial Function in Healthy Individuals N/A
Terminated NCT00942643 - Endothelial Damage and Atherosclerosis in Obstructive Sleep Apnea N/A
Completed NCT05235958 - VascuFit: Exercise and Vascular Aging N/A
Not yet recruiting NCT06288828 - The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis N/A
Completed NCT05396079 - Effect of Tahini in Oxidative Stress and Endothelial Function in Diabetes N/A