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Endothelial Dysfunction clinical trials

View clinical trials related to Endothelial Dysfunction.

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NCT ID: NCT06403241 Completed - Clinical trials for Endothelial Dysfunction

The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.

Start date: May 1, 2023
Phase:
Study type: Observational

The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.

NCT ID: NCT06372262 Completed - Clinical trials for Endothelial Dysfunction

Effect of 2000-meter Rowing Test on Parameters of Intestinal Integrity in Elite Rowers During Competitive Phase

Rowers
Start date: June 1, 2022
Phase:
Study type: Observational

The study aimed to check the 2000m ergometer test on markers of gut permeability in the competitive phase of rowers. 18 members of the Polish rowing team took part in the study.

NCT ID: NCT06355167 Completed - Clinical trials for Cardiovascular Diseases

Effect of Oral Intake of Bacopa Monneiri on Vascular Oxidative Stress

Bacoxy_I
Start date: March 15, 2022
Phase: N/A
Study type: Interventional

Bacoxy_I study aims to evaluate the efficacy of a standardized Bacopa monnieri extract, Bacopa-400®, on vascular oxidative stress.

NCT ID: NCT06163456 Completed - Clinical trials for Endothelial Dysfunction

Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only ~50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.

NCT ID: NCT06071728 Completed - Aging Clinical Trials

Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function

RESTORE
Start date: October 10, 2022
Phase: N/A
Study type: Interventional

The glycocalyx serves as the interface between flowing blood and endothelial cells, the single cell layer that lines blood vessels, and is crucial for normal blood vessel function. Specifically, the glycocalyx protects endothelial cells from oxidative stress and inflammation and enables blood vessel dilation, which is largely dependent on the bioavailability of the vasodilatory molecule nitric oxide. Importantly, glycocalyx thickness decreases with age and is predictive of major adverse cardiovascular events in older adults free of cardiovascular disease. Therefore, interventions aimed at restoring glycocalyx thickness in older adults are desperately needed. Endocalyx Pro is a commercially available glycocalyx precursor supplement, manufactured by Microvascular Health Solutions, designed to 1) repair a damaged glycocalyx, 2) protect against damage to the glycocalyx, and 3) synthesize new glycocalyx components, and has been used to increase glycocalyx thickness in humans. However, no study has tested if glycocalyx thickness restores glycocalyx thickness in older adults and improves blood vessel function. Thus, the purpose of this investigation is to determine if 12-weeks of Endocalyx Pro supplementation alters glycocalyx thickness and blood vessel function in older adults. The investigators will use a camera placed under the tongue to determine glycocalyx thickness. The investigators will measure blood vessel function by measuring brachial artery dilation with ultrasound and arterial stiffness using pressure probes placed on the carotid and femoral artery.

NCT ID: NCT06059131 Completed - Clinical trials for Cardiovascular Diseases

Effect of a Specific Aquaporin-1 Inhibitor on Vascular Oxidative Stress in Healthy Volunteers

Bacoxy_II
Start date: January 3, 2023
Phase: N/A
Study type: Interventional

Bacoxy_II study aims to evaluate the efficacy of a standardized Bacopa monnieri extract, KeenMind®, on vascular oxidative stress.

NCT ID: NCT06018480 Completed - Clinical trials for Endothelial Dysfunction

The Effect of NADPH Oxidase and Creatine Supplementation on Microvascular Blood Flow Regulation

NOXCROS
Start date: August 29, 2023
Phase: N/A
Study type: Interventional

This research study seeks to determine the effects of an enzyme in the human body called NADPH oxidase (NOX) on blood flow. In addition, the study will investigate the benefits of creatine monohydrate, a common sports performance supplement, on blood food and vessel function. Participants will undergo two study arms, one in which they consume a high carbohydrate meal pre- and post-creatine monohydrate supplementation and one in which they will consume a high carbohydrate meal pre- and post-placebo supplementation. Blood flow and endothelial function will be assessed before and for 4 hours following the consumption of a high-carbohydrate meal pre and post-supplementation (creatine monohydrate and placebo).

NCT ID: NCT05957120 Completed - Inflammation Clinical Trials

Subclinical Impairment of Cardiovascular System in Patients With Psoriasis

PaS
Start date: January 3, 2022
Phase:
Study type: Observational

A cross-sectional study will be conducted, which will include 80 young patients with psoriasis, aged 30-45 years, treated with five different types of antipsoriatic treatment, and 20 healthy patients. All 100 subjects will be subjected to anthropometric measurements, blood will be collected for laboratory tests, and an imaging test will be performed to determine the function of the endothelium and arterial stiffness. The results will then be statistically analyzed.

NCT ID: NCT05872139 Completed - Aging Clinical Trials

Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging

Start date: September 23, 2022
Phase: N/A
Study type: Interventional

The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.

NCT ID: NCT05857085 Completed - Clinical trials for Diabetes Mellitus, Type 1

Novel Therapeutics and Endothelial Dysfunction in T1DM Patients

ENDIS
Start date: December 15, 2021
Phase: Phase 4
Study type: Interventional

The aim of study is impact of additional treatment with new antidiabetic drugs (semaglutide or empagliflozine) compared to control group in T1DM patients - impact on endothelial function measured by FMD and FPF, arterial stiffness - measured by PWV, inflammatory biomarkers, markers of oxidative stress and endothelial progenitor cells (CD 34+/VDRL2, CD 133+/VDRL2) and correlation with glucovariability or time in range, measured with CGM system.