Atherosclerotic Cardiovascular Disease (ASCVD) Clinical Trial
Official title:
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event - ACCLAIM-Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin).
| Status | Recruiting |
| Enrollment | 12500 |
| Est. completion date | March 2029 |
| Est. primary completion date | March 2029 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Have Lipoprotein(a) [Lp(a)] =175 nanomoles per liter (nmol/L). - Meet criteria of either 2a or 2b: 2a: Individuals 18 years of age or older with established atherosclerotic cardiovascular disease (ASCVD) with an event or revascularization. 2b: Individuals 55 years of age or older who are at risk for a first cardiovascular (CV) event and either: Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without history of event or revascularization; known familial hypercholesteremia; or a combination of high-risk factors. Exclusion Criteria: - Have had a major cardiovascular event or surgery, such as myocardial infarction (MI), stroke or coronary or peripheral revascularization, < 90 days before screening. - Have uncontrolled hypertension - Have New York Heart Association class IV heart failure. - Have lipoprotein apheresis within 90 days of screening, or planned lipoprotein apheresis during the study. - Have severe renal failure, defined as - Estimated glomerular rate (eGFR) <15 milliliters per minute per 1.73 meters squared (mL/min/1.73m2) at screening Visit 1, or ongoing dialysis. - Have a diagnosis of active nephrotic syndrome, or urine albumin-creatinine ratio (UACR) of =5000 mg/g at screening Visit 1. - Have acute or chronic hepatitis, signs and symptoms of any other liver disease other than nonalcoholic fatty liver disease, or any of these laboratory results as determined by the central laboratory at screening. |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Clínica Privada del Prado SRL | Alberdi | Córdoba |
| Argentina | Buenos Aires Macula S.A | Buenos Aires | |
| Argentina | CEMEDIC | Buenos Aires | |
| Argentina | CIPREC | Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | CIPREC | Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | Consultorio Medico Investigador Principal Dr Besada | Buenos Aires | |
| Argentina | Fundación favaloro para la Docencia e Investigación Médica | Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | Fundación Respirar | Buenos Aires | |
| Argentina | Glenny Corp | Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | Instituto Cardiovascular de Buenos Aires | Buenos Aires | |
| Argentina | Instituto Médico Especializado (IME) | Buenos Aires | |
| Argentina | Investigaciones Medicas Imoba Srl | Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | Stat Research S.A. | Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | CEDIC | Caba | Buenos Aires |
| Argentina | Clinica Adventista Belgrano | Caba | Ciudad Autónoma De Buenos Aires |
| Argentina | Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada | Ciudad Autonoma de Buenos Aires | Ciudad Autónoma De Buenos Aires |
| Argentina | Consultorio Medico Dr Litvak Bruno | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Centro de Investigaciones Metabólicas (CINME) | Ciudad Autónoma de Buenos Aires | Buenos Aires |
| Argentina | IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas | Ciudad de Buenos Aires | Buenos Aires |
| Argentina | Centro Médico Colón | Córdoba | |
| Argentina | Instituto de Investigaciones Clínicas Córdoba | Córdoba | |
| Argentina | Sanatorio Privado Duarte Quirós | Córdoba | |
| Argentina | Instituto de Cardiología "Juana F. Cabral" | Corrientes | |
| Argentina | MICA - Medicina e Investigación Cardiometabólica | Del Viso | Buenos Aires |
| Argentina | CIPADI - Centro Integral de Prevencion y Atencion en Diabetes | Godoy Cruz | Mendoza |
| Argentina | Centro de Investigaciones Clínicas Baigorria | Granadero Baigorria | Santa Fe |
| Argentina | Hospital Italiano de La Plata | La Plata | Buenos Aires |
| Argentina | CIMeL Clinical Research | Lanus | Buenos Aires |
| Argentina | Centro de Investigaciones Médicas Mar del Plata | Mar del Plata | Buenos Aires |
| Argentina | Instituto de Investigaciones Clínicas Mar del Plata | Mar del Plata | Buenos Aires |
| Argentina | Instituto de Cardiología Wolff | Mendoza | |
| Argentina | Clínica Privada Independencia | Munro | Buenos Aires |
| Argentina | Centro Privado de Medicina Respiratoria | Paraná | Entre Ríos |
| Argentina | Instituto De Investigaciones Clinicas Quilmes | Quilmes | Buenos Aires |
| Argentina | DIM Clínica Privada | Ramos Mejía | Buenos Aires |
| Argentina | Instituto Médico Río Cuarto | Río Cuarto | Córdoba |
| Argentina | Fundacion Estudios Clinicos | Rosario | Santa Fe |
| Argentina | Hospital Provincial del Centenario | Rosario | Santa Fe |
| Argentina | INECO Neurociencias Oroño | Rosario | Santa Fe |
| Argentina | Instituto de Especialidades de la Salud Rosario | Rosario | Santa Fe |
| Argentina | Instituto de Investigaciones Clinicas Rosario | Rosario | Santa Fe |
| Argentina | Instituto Médico Catamarca IMEC | Rosario | Santa Fe |
| Argentina | Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica | Rosario | Santa Fe |
| Argentina | Laboratorio de Hemostasia y Trombosis | Rosario | Santa Fe |
| Argentina | Centro Cardiovascular Salta | Salta | |
| Argentina | Corporación Médica San Martín | San Martín | Buenos Aires |
| Argentina | Centro Modelo de Cardiología | San Miguel de Tucuman | Tucumán |
| Argentina | Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L | San Miguel de Tucuman | Tucumán |
| Argentina | Investigaciones Clínicas Tucumán | San Miguel de Tucuman | Tucumán |
| Argentina | Go Centro Medico San Nicolás | San Nicolas | Buenos Aires |
| Argentina | Centro de Diagnóstico y Rehabilitación (CEDIR) | Santa Fe | |
| Argentina | Centro de Investigaciones Clinicas del Litoral | Santa Fe | |
| Argentina | Clínica de Nefrología, Urología y Enfermedades Cardiovasculares | Santa Fe | |
| Argentina | Sanatorio San Martin | Venado Tuerto | Santa Fe |
| Australia | Adelaide Cardiology | Adelaide | South Australia |
| Australia | Fusion Clinical Research | Adelaide | South Australia |
| Australia | Nightingale Research | Adelaide | South Australia |
| Australia | Paratus Clinical Research Western Sydney | Blacktown | New South Wales |
| Australia | Optimus Clinical Research | Botany | New South Wales |
| Australia | Cholesterol Care | Brisbane | Queensland |
| Australia | Core Research Group | Brisbane | Queensland |
| Australia | Heart of Australia | Brisbane | Queensland |
| Australia | Royal Brisbane and Women's Hospital | Brisbane | Queensland |
| Australia | Northern Beaches Clinical Research | Brookvale | New South Wales |
| Australia | Paratus Clinical Research Canberra | Bruce | Australian Capital Territory |
| Australia | Emeritus Research | Camberwell | Victoria |
| Australia | Victorian Heart Hospital | Clayton | Victoria |
| Australia | Barwon Health | Geelong | Victoria |
| Australia | Austin Health - Repatriation Hospital | Heidelberg West | Victoria |
| Australia | Paratus Clinical Research Brisbane | Herston | Queensland |
| Australia | GenesisCare | Joondalup | Western Australia |
| Australia | Paratus Clinical Research Central Coast | Kanwal | New South Wales |
| Australia | Liverpool Hospital | Liverpool | New South Wales |
| Australia | Logan Hospital | Meadowbrook | Queensland |
| Australia | AusTrials - Sunshine | Melbourne | Victoria |
| Australia | The AIM Centre / Hunter Diabetes Centre | Merewether | New South Wales |
| Australia | Mount Isa Base Hospital | Mount Isa | Queensland |
| Australia | Advara HeartCare - Mulgrave | Mulgrave | Victoria |
| Australia | Clinitrials | Perth | Western Australia |
| Australia | AusTrials - St. Leonards | Sydney | New South Wales |
| Australia | The Townsville Hospital | Townsville | Queensland |
| Austria | Krankenhaus St. Josef Braunau | Braunau | Oberösterreich |
| Austria | VIVIT | Feldkirch | Vorarlberg |
| Austria | Medizinische Universitaet Innsbruck | Innsbruck | Tirol |
| Austria | Konventhospital der Barmherzigen Brüder Linz | Linz | Oberösterreich |
| Austria | Ordensklinikum Linz GmbH Elisabethinen | Linz | Oberösterreich |
| Austria | Landesklinikum Mistelbach | Mistelbach | Niederösterreich |
| Austria | Uniklinikum Salzburg | Salzburg | |
| Austria | Universitätsklinikum St. Pölten | St. Polten | Niederösterreich |
| Austria | Herz Zentrum Währing - Innere Medizin und Kardiologie | Alle Kassen und Privat | Vienna | Wien |
| Austria | Medizinische Universität Wien | Vienna | Wien |
| Austria | Medizinische Universität Wien | Vienna | Wien |
| Austria | Zentrum für klinische Studien Dr Hanusch Gmbh | Vienna | Wien |
| Austria | Klinik Floridsdorf | Wien | |
| Austria | Klinik Hietzing | Wien | |
| Austria | Klinik Landstraße | Wien | |
| Belgium | ZNA Middelheim | Antwerp | Antwerpen |
| Belgium | Imelda General Hospital | Bonheiden | Antwerpen |
| Belgium | Algemeen Ziekenhuis klina | Brasschaat | Antwerpen |
| Belgium | Centre Hospitalier Universitaire Brugmann | Brussels | Bruxelles-Capitale, Région De |
| Belgium | Cliniques universitaires Saint-Luc | Brussels | Bruxelles-Capitale, Région De |
| Belgium | Université Libre de Bruxelles - Hôpital Erasme | Brussels | Bruxelles-Capitale, Région De |
| Belgium | AZ Sint-Blasius | Dendermonde | Oost-Vlaanderen |
| Belgium | Antwerp University Hospital | Edegem | Antwerpen |
| Belgium | Ziekenhuis Oost-Limburg, Campus St.-Jan | Genk | Limburg |
| Belgium | AZ Maria Middelares | Gent | Oost-Vlaanderen |
| Belgium | UZ Gent | Gent | Oost-Vlaanderen |
| Belgium | Grand Hôpital de Charleroi | Gilly | Hainaut |
| Belgium | Jessa Ziekenhuis | Hasselt | Limburg |
| Belgium | AZ Groeninge Campus Kennedylaan | Kortrijk | West-Vlaanderen |
| Belgium | UZ Leuven | Leuven | Vlaams-Brabant |
| Belgium | AZ Sint-Maarten, Campus Leopoldstraat 2 | Mechelen | Antwerpen |
| Belgium | Az Damiaan vzw | Oostende | West-Vlaanderen |
| Brazil | Centro de Pesquisa Clinica do Coracao | Aracaju | Sergipe |
| Brazil | Instituto Aramari Apo | Asa Norte | |
| Brazil | Hospital Universitário João de Barros Barreto | Belem | Pará |
| Brazil | Consultoria em Controle de Infecção Hospitalar | Belo Horizonte | Minas Gerais |
| Brazil | NUPEC - Cardio | Belo Horizonte | Minas Gerais |
| Brazil | Santa Casa de Misericordia de Belo Horizonte | Belo Horizonte | Minas Gerais |
| Brazil | Hospital São Domingos | Bequimao | Maranhão |
| Brazil | AngioCor Blumenau | Blumenau | Santa Catarina |
| Brazil | Hospital Brasilia | Brasilia | Distrito Federal |
| Brazil | Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Brasília | Brasilia | Distrito Federal |
| Brazil | Chronos Pesquisa Clínica | Brasília | Distrito Federal |
| Brazil | L2IP - Instituto de Pesquisas Clínicas - FC072920211954380192 | Brasília | Distrito Federal |
| Brazil | Centro de Pesquisa Sao Lucas | Campinas | São Paulo |
| Brazil | Nucleo De Pesquisa Clinica | Curitiba | Paraná |
| Brazil | Pesquisa Clínica em Diabetes - Dra Rosângela Réa | Curitiba | Paraná |
| Brazil | PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR | Curitiba | Paraná |
| Brazil | Universidade Federal de Goias | Goiania | Goiás |
| Brazil | Centro de Pesquisas Clínicas Dr. Marco Mota | Maceio | Alagoas |
| Brazil | Instituto Do Coracao De Marilia | Marilia | São Paulo |
| Brazil | CHN - Complexo Hospitalar de Niterói | Niteroi | Rio De Janeiro |
| Brazil | Instituto Méderi de Pesquisa e Saúde | Passo Fundo | Rio Grande Do Sul |
| Brazil | Hospital de Clinicas de Porto Alegre | Porto Alegre | Rio Grande Do Sul |
| Brazil | Hospital Moinhos de Vento | Porto Alegre | Rio Grande Do Sul |
| Brazil | Hospital Nossa Senhora da Conceição | Porto Alegre | Rio Grande Do Sul |
| Brazil | Hospital São Lucas da PUCRS | Porto Alegre | Rio Grande Do Sul |
| Brazil | Núcleo de Pesquisa Clínica do Rio Grande do Sul | Porto Alegre | Rio Grande Do Sul |
| Brazil | Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco | Recife | Pernambuco |
| Brazil | CAPED Centro Avancado Pesquisa e Diagnostica | Ribeirao Preto | São Paulo |
| Brazil | Hospital Pro-Cardiaco | Rio de Janeiro | |
| Brazil | Hospital São Lucas Copacabana | Rio de Janeiro | |
| Brazil | IBPClin - Instituto Brasil de Pesquisa Clínica | Rio de Janeiro | |
| Brazil | Instituto D'Or Pesquisa e Ensino | Rio de Janeiro | |
| Brazil | Hospital Ana Nery (HAN) - Salvador | Salvador | Bahia |
| Brazil | Hospital Da Bahia | Salvador | Bahia |
| Brazil | Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador | Salvador | Bahia |
| Brazil | Faculdade de Medicina do ABC | Santo Andre | São Paulo |
| Brazil | Praxis Pesquisa Medica | Santo Andre | São Paulo |
| Brazil | Centro Multidisciplinar de Estudos Clinicos | Sao Bernardo do Campo | São Paulo |
| Brazil | Fundação Faculdade Regional de Medicina de São José do Rio Preto | São José do Rio Preto | São Paulo |
| Brazil | Centro Internacional de Pesquisa Clínica (CIPES) | São José dos Campos | São Paulo |
| Brazil | CPCLIN | Sao Paulo | São Paulo |
| Brazil | Hospital Alemao Oswaldo Cruz | Sao Paulo | São Paulo |
| Brazil | Incor - Instituto do Coracao | Sao Paulo | São Paulo |
| Brazil | CEPIC - Centro Paulista de Investigação Clínica | São Paulo | |
| Brazil | CPQuali Pesquisa Clínica | São Paulo | |
| Brazil | Hospital 9 De Julho | São Paulo | |
| Brazil | Hospital BP | São Paulo | |
| Brazil | Hospital do Coracao | São Paulo | |
| Brazil | Instituto Dante Pazzanese de Cardiology | São Paulo | |
| Brazil | Núcleo de Pesquisa Clínica da Rede São Camilo | São Paulo | |
| Brazil | Instituto de Molestias Cardiovasculares de Tatui | Tatui | São Paulo |
| Brazil | Eurolatino Pesquisas Medicas | Uberlandia | Minas Gerais |
| Brazil | CEDOES | Vitória | Espírito Santo |
| Brazil | Integral Pesquisa e Ensino | Votuporanga | São Paulo |
| Canada | Cardio Health Clinical Trial - Brampton | Brampton | Ontario |
| Canada | Ecogene-21 | Chicoutimi | Quebec |
| Canada | Viacar Recherche Clinique | Greenfield Park | Quebec |
| Canada | Hamilton Medical Research Group | Hamilton | Ontario |
| Canada | Cardio Health Clinical Trial - London | London | Ontario |
| Canada | G A Research Associates | Moncton | New Brunswick |
| Canada | Fraser Clinical Trials Inc | New Westminster | British Columbia |
| Canada | North York Diagnostic and Cardiac Centre | North York | Ontario |
| Canada | Oakville Cardiovascular Research LP | Oakville | Ontario |
| Canada | Clinique des Maladies Lipidiques de Québec | Québec | Quebec |
| Canada | Diex Recherche Joliette | Saint-Charles-Borromée | Quebec |
| Canada | Unité de Recherche Clinique du CISSS des Laurentides | St-Jerome | Quebec |
| Canada | Cardio Health Clinical Trial - St. Thomas | St. Thomas | Ontario |
| Canada | SMH Cardiology Clinical Trials | Surrey | British Columbia |
| Canada | Care Access - Cape Breton | Sydney | Nova Scotia |
| Canada | Centre de Medecine Metabolique de Lanaudiere (CMML) | Terrebonne | Quebec |
| Canada | Corcare | Toronto | Ontario |
| Canada | Diabetes Heart Research Centre | Toronto | Ontario |
| Canada | Diex Recherche Trois-Rivieres | Trois-Rivieres | Quebec |
| Canada | The Medical Arts Health Research Group | Vancouver | British Columbia |
| Canada | Discovery Clinical Services | Victoria | British Columbia |
| Canada | Victoria Heart Institute Foundation | Victoria | British Columbia |
| Canada | Winnipeg Clinic | Winnipeg | Manitoba |
| China | Beijing ChaoYang Hospital | Beijing | Beijing |
| China | Beijing Friendship Hospital | Beijing | Beijing |
| China | Peking University Third Hospital | Beijing | Beijing |
| China | China-Japan Union Hospital | Changchun | Jilin |
| China | The First Hospital of Jilin University | Changchun | Jilin |
| China | Changde First People's Hospital | Changde | Hunan |
| China | The Third Xiangya Hospital of Central South University | Changsha | Hunan |
| China | Changzhou Second People's Hospital | Changzhou | Jiangsu |
| China | West China Hospital, Sichuan University | Cheng Du | Sichuan |
| China | Sichuan Provincial People's Hospital | Chengdu | Sichuan |
| China | Chifeng Hospital | Chifeng | Inner Mongolia |
| China | 2nd Affiliated Hospital Chongqing Medical Universi | Chongqing | Chongqing |
| China | Dalian Municipal Central Hospital Affiliated of Dalian Medical University | Dalian | Liaoning |
| China | Shunde Hospital of Southern Medical Univesity | Foshan | Guangdong |
| China | Guangdong Provincial People's Hospital | Guangzhou | Guangdong |
| China | Guangzhou First People's Hospital | Guangzhou | Guangdong |
| China | The First Affiliated Hospital, Sun Yat-sen University | Guangzhou | Guangdong |
| China | Sir Run Run Shaw Hospital | Hangzhou | Zhejiang |
| China | The First Hospital of Harbin Medical University | Harbin | Heilongjiang |
| China | The Fourth Hospital of Harbin Medical University | Harbin | Heilongjiang |
| China | Anhui Provincil Hospital South District | Hefei | Anhui |
| China | The Second People's Hospital of Hefei | Hefei | Anhui |
| China | Inner Mongolia People's Hospital | Hohhot | Inner Mongolia |
| China | Huizhou Municipal Central Hospital | Huizhou | Guangdong |
| China | Jinan Central Hospital | Jinan | Shandong |
| China | Jinan Central Hospital | Jinan | Shandong |
| China | Jingzhou Central Hospital | Jingzhou | Hubei |
| China | Jining Medical University - Affiliated Hospital | Jining | Shandong |
| China | Lanzhou university second hospital | Lanzhou | Gansu |
| China | The First Hospital of Lanzhou University | Lanzhou | Gansu |
| China | Lishui Central Hospital | Lishui City | Zhejiang |
| China | The First Affiliated Hospital of Henan University of Science &Technology | Luoyang | Henan |
| China | The First Affiliated Hospital of Henan University of Science &Technology | Luoyang | Henan |
| China | The Second Affiliated Hospital of Nanchang University | Nanchang | Jiangxi |
| China | The Third Hospital of Nanchang | Nanchang | Jiangxi |
| China | Jiangsu Province Hospital | Nanjing | Jiangsu |
| China | Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School | Nanjing | Jiangsu |
| China | The Second Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu |
| China | The Second Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu |
| China | Zhongda Hospital Southeast University | Nanjing | Jiangsu |
| China | Guangxi People's Hospital | Nanning | Guangxi |
| China | The First Affiliated Hospital of Nanyang Medical College | Nanyang | Henan |
| China | The First Affiliated Hospital of Nanyang Medical College | Nanyang | Henan |
| China | Ningbo First Hospital | Ningbo | Zhejiang |
| China | Shanghai East Hospital | Shanghai | |
| China | Zhongshan Hospital,Fudan University | Shanghai | Shanghai |
| China | The People's Hospital of Liaoning Province | Shenyang | Liaoning |
| China | Shenzhen Sun Yat-sen Cardiovascular Hospital | Shenzhen | Guangdong |
| China | Siping Central People's Hospital | Siping | Jilin |
| China | TEDA International Cardiovascular Hospital | Tianjin | Tianjin |
| China | Tianjin Fourth Centre Hospital | Tianjin | Tianjin |
| China | The First Affiliated Hospital of Xinjiang Medical University | Urumchi | Xinjiang |
| China | People's Hospital of Xinjiang Uygur Autonomous Region | Urumqi | Xinjiang |
| China | Chongqing Three Gorges Central Hospital | Wanzhou | Chongqing |
| China | The First Affiliated Hospital of Wenzhou Medical University | Wenzhou | Zhejiang |
| China | Renmin Hospital of Wuhan University | Wuhan | Hubei |
| China | Wuhan Asia Heart Hospital | Wuhan | Hubei |
| China | Wuhan University Medical College - Hubei Zhongshan Hospital | Wuhan | Hubei |
| China | Wannan Medical College Yijishan Hospital | Wuhu | Anhui |
| China | Wuxi People's Hospital | Wuxi | Jiangsu |
| China | Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army | Xi'an | Shaanxi |
| China | The First Affiliated Hospital of Xi'an Jiaotong University | Xi'an | Shaanxi |
| China | Xiamen Cardiovascular Hospital | Xiamen | Fujian |
| China | Shaanxi provincial people's hospital | Xian | Shaanxi |
| China | The Affiliated Hospital of Xuzhou Medical College | Xuzhou | Jiangsu |
| China | General Hospital of Ningxia Medical University | Yinchuan | |
| China | The First People's Hospital of Yueyang | Yueyang | Hunan |
| China | The Second Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan |
| Czechia | Kardiologicka ambulance | Brandýs nad Labem-Stará Boleslav | Praha-východ |
| Czechia | EFERTUS healthcare s.r.o. | Brno | Brno-mesto |
| Czechia | Fakultni Nemocnice u sv. Anny v Brne | Brno | Brno-mesto |
| Czechia | Fakultni Nemocnice u sv. Anny v Brne | Brno | Jihomoravský Kraj |
| Czechia | Kardiologická ambulance Brno | Brno | Brno-mesto |
| Czechia | Vojenská Nemocnice Brno | Brno | Brno-mesto |
| Czechia | Kardioma | Kolin | Stredoceský Kraj |
| Czechia | Kardiologicka ambulance | Litovel | Olomoucký Kraj |
| Czechia | EDUMED - Náchod | Nachod | Královéhradecký Kraj |
| Czechia | Agentura Science Pro | Olomouc | Olomoucký Kraj |
| Czechia | PreventaMed | Olomouc | |
| Czechia | Kardiologicka a Angiologicka Ambulance | Ostrava | Ostrava Mesto |
| Czechia | Private Practice - Dr. Miroslav Koliba | Ostrava | Ostrava Mesto |
| Czechia | Angiocentrum Komorany | Prague | Praha 12 |
| Czechia | Centrum Kardiovaskularni Mediciny | Prague | Praha 6 |
| Czechia | Kardio Uhrineves | Prague | Praha, Hlavní Mešto |
| Czechia | Nefrologie | Prague | Praha 4 |
| Czechia | Poliklinika Lípa Centrum | Prague | Praha 13 |
| Czechia | Synexus Czech | Prague | Praha 2 |
| Czechia | DiaVize s.r.o. | Praha | Praha 4 |
| Czechia | Nova kardiologie - Kardiologicka ambulance | Ricany | Stredoceský Kraj |
| Czechia | Kardiologicka ambulance MUDr. Ferkl s.r.o. | Trutnov | |
| Czechia | Clinical Trials Service s.r.o. | Uherské Hradište | Zlínský Kraj |
| Czechia | Cardio Research, s.r.o | Zlín | |
| Denmark | Sygehus Sønderjylland i Aabenraa | Aabenraa | Syddanmark |
| Denmark | Aarhus Universitetshospital, Skejby | Aarhus | Midtjylland |
| Denmark | Rigshospitalet | Copenhagen | Hovedstaden |
| Denmark | Sydvestjysk Sygehus Esbjerg | Esbjerg | Syddanmark |
| Denmark | Sanos Clinic - Nordjylland | Gandrup | Nordjylland |
| Denmark | Herlev and Gentofte Hospital | Hellerup | Hovedstaden |
| Denmark | Sanos Clinic | Herlev | Hovedstaden |
| Denmark | Holbæk Sygehus | Holbaek | Sjælland |
| Denmark | Sanos Clinic - Syddanmark | Vejle | Syddanmark |
| France | CHU Besançon | Besançon | Doubs |
| France | Hôpital Avicenne | Bobigny | Île-de-France |
| France | Hospices Civils de Lyon - Hopital Louis Pradel | Bron | Rhône |
| France | CHRU Troussau | Chambray Les Tours | Centre |
| France | Centre Hospitalier Compiègne-Noyon | Compiègne | Oise |
| France | Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand | Dijon | Bourgogne |
| France | Centre Hospitalier Louis Pasteur | Le Coudray | Eure-et-Loir |
| France | Hopital Claude Huriez - CHU de Lille | Lille | Nord |
| France | Centre Hospitalier Saint Joseph - Saint Luc | Lyon | Rhône-Alpes |
| France | Hôpital Saint Joseph | Marseille | Bouches-du-Rhône |
| France | CHU Montpellier Lapeyronie Hospital | Montpellier | Hérault |
| France | Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes | Nantes Cedex 1 | Loire-Atlantique |
| France | CHU de Nice | Nice | Alpes-Maritimes |
| France | Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau | Nîmes | Gard |
| France | Hôpital Bichat - Claude-Bernard | Paris | |
| France | Hôpital Européen Georges Pompidou | Paris | Île-de-France |
| France | Hôpital Saint Antoine | Paris | Île-de-France |
| France | Pitie Salpetriere University Hospital | Paris | Orne |
| France | Centre Hospitalier de Pau | Pau | Pyrénées-Atlantiques |
| France | CHU Bordeaux Haut-Leveque | Pessac | Aquitaine |
| France | Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou | Rennes | Bretagne |
| France | CHU Charles Nicolle | Rouen | Haute-Normandie |
| France | CHU Strasbourg-Hautepierre | Strasbourg | Alsace |
| France | CHU Rangueil | Toulouse | Haute-Garonne |
| France | Polyclinique Vauban | Valenciennes | |
| Germany | Universitätsklinikum Aachen | Aachen | Nordrhein-Westfalen |
| Germany | Klinikum am Plattenwald | Bad Friedrichshall | |
| Germany | Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair | Bad Homburg | Hessen |
| Germany | Charité Campus Virchow-Klinikum | Berlin | |
| Germany | DRK Kliniken Berlin - Köpenick | Berlin | |
| Germany | Kardiologische Praxen im Spreebogen | Berlin | |
| Germany | Praxis Rankestrasse | Berlin | |
| Germany | Klinikum Bielefeld Mitte | Bielefeld | Nordrhein-Westfalen |
| Germany | Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien | Dresden | Sachsen |
| Germany | Herzzentrum Dresden GmbH Universitätsklinik | Dresden | Sachsen |
| Germany | Universitaetsklinikum Carl Gustav Carus Dresden | Dresden | Sachsen |
| Germany | Medizentrum Essen Borbeck | Essen | Nordrhein-Westfalen |
| Germany | Cardioangiologisches Centrum Bethanien | Frankfurt | Hessen |
| Germany | Diabetes Zentrum Dr. Tews | Gelnhausen | Hessen |
| Germany | Cardiologicum Hamburg | Hamburg | |
| Germany | Universitätsklinikum Jena | Jena | Thüringen |
| Germany | University Hospital of Cologne | Köln | Nordrhein-Westfalen |
| Germany | Herzzentrum Leipzig GmbH | Leipzig | Sachsen |
| Germany | Universitätsklinikum Leipzig | Leipzig | Sachsen |
| Germany | Praxis Oedeme | Lüneburg | Niedersachsen |
| Germany | Otto-von-Guericke-Universität Magdeburg | Magdeburg | Sachsen-Anhalt |
| Germany | Universitätsmedizin Mannheim | Mannheim | Baden-Württemberg |
| Germany | ze:ro ARZTPRAXEN | Mannheim | Baden-Württemberg |
| Germany | Deutsches Herzzentrum München | Munich | Bayern |
| Germany | Institut für Diabetesforschung GmbH Münster | Münster | Nordrhein-Westfalen |
| Germany | Kardiologische Gemeinschaftspraxis am Park Sanssouci | Potsdam | Brandenburg |
| Germany | Universitätsklinikum Regensburg | Regensburg | Bayern |
| Germany | Universitaet zu Koeln - Sana-Klinikum Remscheid GmbH - Klinik fuer Kardiologie, Pneumologie und Internisti -T | Remscheid | Nordrhein-Westfalen |
| Germany | GPR Gesundheits- und Pflegezentrum Rüsselsheim | Rüsselsheim | Hessen |
| Germany | Zentrum für klinische Studien | Saint Ingbert | Saarland |
| Germany | Studienzentrum Herzklinik Ulm MVZ | Ulm | Baden-Württemberg |
| Greece | Athens Medical Center | Athens | Attikí |
| Greece | Athens Naval Hospital | Athens | Attikí |
| Greece | General Hospital of Athens Laiko | Athens | Attikí |
| Greece | Attikon General University Hospital | Chaidari | Attikí |
| Greece | University General Hospital of Heraklion | Heraklion | Irakleío |
| Greece | University Hospital of Ioannina | Ioannina | Ioánnina |
| Greece | Iatriko Paleou Falirou Medical Center | Paleo Faliro | Attikí (Region) |
| Greece | AHEPA University General Hospital of Thessaloniki | Thessaloniki | Kentrikí Makedonía |
| Greece | Papageorgiou General Hospital of Thessaloniki | Thessaloniki | Thessaloníki |
| Hungary | DRC Gyógyszervizsgáló Központ | Balatongyorok | Veszprém |
| Hungary | Magyar Honvedseg Egeszsegugyi Kozpont | Budapest | |
| Hungary | Privát Doktor Egészségügyi Zrt | Budapest | |
| Hungary | Semmelweis University | Budapest | |
| Hungary | Szent Margit Rendelointézet Nonprofit Kft | Budapest | |
| Hungary | Debreceni Egyetem Klinikai Kozpont | Debrecen | |
| Hungary | Medifarma 98 Kft | Nyiregyhaza | Nyíregyháza |
| Hungary | Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ | Szeged | Csongrád |
| Hungary | Vita Verum Medical Egeszsegugyi Szolgaltato | Szekesfehervar | Fejér |
| Hungary | Belvárosi Egészségház | Zalaegerszeg | Zala |
| India | KLES Dr. Prabhakar Kore Hospital & M.R.C | Belagavi | Karnataka |
| India | Sardar Patel Medical College | Bikaner | Rajasthan |
| India | Shri Mahant Indiresh Hospital | Dehradun | Uttarakhand |
| India | K care Hospital | Kanpur | Uttar Pradesh |
| India | Lisie Hospital | Kochi | Kerala |
| India | Government Medical College - Kozhikode | Kozhikode | Kerala |
| India | King George's Medical University | Lucknow | Uttar Pradesh |
| India | Vijan Hospital & Research Centre | Nashik | Maharashtra |
| India | G.B. Pant Institute of Postgraduate Medical Education & Research | New Delhi | Delhi |
| India | All India Institute of Medical Sciences | Raipur | Chhattisgarh |
| Israel | Soroka Medical Center | Be'er Sheva | HaDarom |
| Israel | Carmel Hospital | Haifa | ?eifa |
| Israel | Rambam Health Care Campus | Haifa | ?eifa |
| Israel | Rambam Health Care Campus | Haifa | HaTsafon |
| Israel | Edith Wolfson Medical Center | Holon | HaMerkaz |
| Israel | Hadassah Medical Center | Jerusalem | Yerushalayim |
| Israel | Hadassah Medical Center | Jerusalem | Yerushalayim |
| Israel | Shaare Zedek Medical Center | Jerusalem | Yerushalayim |
| Israel | Meir Medical Center | Kfar Saba | HaMerkaz |
| Israel | Galilee Medical Center | Nahariya | HaTsafon |
| Israel | Rabin Medical Center | Petah Tikva | HaMerkaz |
| Israel | Rabin Medical Center | Petah-Tikva | HaMerkaz |
| Israel | Sheba Medical Center | Ramat Gan | HaMerkaz |
| Israel | Sheba Medical Center | Ramat Gan | HaMerkaz |
| Israel | Kaplan Medical Center | Rehovot | HaMerkaz |
| Israel | Sourasky Medical Center | Tel Aviv | Tell Abib |
| Israel | Sourasky Medical Center | Tel Aviv | Tell Abib |
| Italy | Ospedale Cazzavillan di Arzignano | Arzignano | Veneto |
| Italy | Ospedale di Baggiovara | Baggiovara | Modena |
| Italy | IRCCS - AOU di Bologna | Bologna | |
| Italy | Ospedale Bassini | Cinisello Balsamo | Milano |
| Italy | Azienda Ospedaliero Universitaria S.Anna | Ferrara | Emilia-Romagna |
| Italy | Azienda Ospedaliera Universitaria Careggi | Firenze | Toscana |
| Italy | Ospedale San Martino | Genova | Liguria |
| Italy | ASST Grande Ospedale Metropolitano Niguarda | Milan | Milano |
| Italy | Centro Cardiologico Monzino | Milan | Milano |
| Italy | Ospedale San Raffaele | Milano | |
| Italy | Azienda Ospedaliera di Padova | Padova | Veneto |
| Italy | Hospital Santa Maria della Misericordia in Perugia | Perugia | |
| Italy | Azienda Ospedaliera Universitaria Pisana | Pisa | Toscana |
| Italy | Fondazione G. Monasterio | Pisa | Toscana |
| Italy | Policlinico Umberto I | Rome | Lazio |
| Japan | Asahi Hospital - Asahi | Asahi | Chiba |
| Japan | Asahikawa City Hospital | Asahikawa | Hokkaido |
| Japan | Saiseikai Futsukaichi Hospital | Chikushino | Fukuoka |
| Japan | University of Yamanashi Hospital | Chuo | Yamanashi |
| Japan | Fukuwa Clinic | Chuo-ku | Tokyo |
| Japan | The Institute for Adult Disease, Asahi Life Foundation | Chuo-ku | Tokyo |
| Japan | Fukuoka Wajiro Hospital | Fukuoka | |
| Japan | Hospital Hakodate Hokkaido | Hakodate | Hokkaido |
| Japan | Public Matto Ishikawa Central Hospital | Hakusan | Ishikawa |
| Japan | Hyogo Prefectural Harima-Himeji General Medical Center | Himeji | Hyogo |
| Japan | Tokai University Hospital- Isehara Campus | Isehara | Kanagawa |
| Japan | Rinku General Medical Center | Izumisano | Osaka |
| Japan | Tenyoukai Chuo Clinic | Kagoshima | |
| Japan | Takai Internal Medicine Clinic | Kamakura-shi | Kanagawa |
| Japan | Ishikawa Prefectural Central Hospital | Kanazawa | Ishikawa |
| Japan | National Hospital Organization Kanazawa Medical Center | Kanazawa | Ishikawa |
| Japan | Kasugai Municipal Hospital | Kasugai | Aichi |
| Japan | Kokura Memorial Hospital | Kitakyushu | Fukuoka |
| Japan | Kobe City Medical Center General Hospital | Kobe | Hyogo |
| Japan | Komatsu Municipal Hospital | Komatsu | Ishikawa |
| Japan | Jinnouchi Hospital | Kumamoto | |
| Japan | Kurashiki Central Hospital | Kurashiki | Okayama |
| Japan | Chugoku Rosai Hospital | Kure | Hiroshima |
| Japan | Rakuwakai Marutamachi Hospital | Kyoto | |
| Japan | Rakuwakai Otowa Hospital | Kyoto | |
| Japan | Aizawa Hospital | Matsumoto | Nagano |
| Japan | National Hospital Organization Tokyo Medical Center | Meguro-ku | Tokyo |
| Japan | Miyakonojo Medical Association Hospital - Tarobocho | Miyakonojo | Miyazaki |
| Japan | Miyazaki Medical Association Hospital | Miyazaki | |
| Japan | Iwate Prefectural Central Hospital | Morioka | Iwate |
| Japan | Tachikawa Medical Center | Nagaoka | Niigata |
| Japan | Nagoya City University Hospital | Nagoya | Aichi |
| Japan | Shonan Oiso Hospital | Naka-gun | Kanagawa |
| Japan | Nogata Clinic | Nakano-ku | Tokyo |
| Japan | International University of Health and Welfare Hospital | Nasushiobara | Tochigi |
| Japan | National Hospital Organization Okayama Medical Center | Okayama | |
| Japan | Okayama City General Medical Center Okayama City Hospital | Okayama | |
| Japan | Medical Corporation Sato Medical clinic | Ootaku | Tokyo |
| Japan | Kansai Electric Power Hospital | Osaka | |
| Japan | National Hospital Organization - Osaka National Hospital - Institute For Clinical Research | Osaka | |
| Japan | Osaka General Medical Center | Osaka | |
| Japan | Osaka Police Hospital | Osaka | |
| Japan | Osaki Citizen Hospital - Furukawahonami | Osaki | Miyagi |
| Japan | Saga University Hospital | Saga | |
| Japan | Kitasato University Hospital | Sagamihara | Kanagawa |
| Japan | Sanai Hospital - Saitama | Saitama | |
| Japan | Japan Community Healthcare Organization Hokkaido Hospital | Sapporo | Hokkaido |
| Japan | Sapporo Medical University Hospital | Sapporo | Hokkaido |
| Japan | Tokeidai Memorial Hospital | Sapporo | Hokkaido |
| Japan | Heishinkai Medical Group ToCROM Clinic | Shinjuku-ku | Tokyo |
| Japan | Center Hospital of the National Center for Global Health and Medicine | Shinjyuku-ku | Tokyo |
| Japan | Tokuyama Central Hospital | Shunan | Yamaguchi |
| Japan | National Cerebral and Cardiovascular Center | Suita | Osaka |
| Japan | Medical Corporation Heishinkai OCROM Clinic | Suita-shi | Osaka |
| Japan | Shizuoka Medical Center | Sunto-gun | Shizuoka |
| Japan | Kagawa Prefectural Central Hospital | Takamatsu | Kagawa |
| Japan | Higashi Takarazuka Satoh Hospital | Takarazuka | Hyogo |
| Japan | Takasago Seibu Hospital | Takasago | Hyogo |
| Japan | Osaka Medical and Pharmaceutical University Hospital | Takatsuki | Osaka |
| Japan | Sekino Hospital | Toshimaku | Tokyo |
| Japan | Toyama University Hospital | Toyoma | Toyama |
| Japan | Tsuchiura Kyodo General Hospital | Tsuchiura | Ibaraki |
| Japan | Kanazawa Medical University Hospital | Uchinada | Ishikawa |
| Japan | National Hospital Organization Shinshu Ueda Medical Center | Ueda | Nagano |
| Japan | Saiseikai Yokohamashi Tobu Hospital | Yokohama | Kanagawa |
| Japan | Yokosukakyosai | Yokosuka | Kanagawa |
| Korea, Republic of | The Catholic University of Korea, Bucheon St. Mary's Hospital | Bucheon-si | Kyonggi-do |
| Korea, Republic of | Daegu Catholic University Medical Center | Daegu | Taegu-Kwangyokshi |
| Korea, Republic of | Keimyung University Dongsan Hospital | Daegu | Taegu-Kwangyokshi |
| Korea, Republic of | Eulji University Hospital | Daejeon | Taejon-Kwangyokshi |
| Korea, Republic of | Boramae Medical Center | Dongjak-gu | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Boramae Medical Center | Dongjak-gu | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Chonnam National University Hospital | Gwangju-si | Kwangju-Kwangyokshi |
| Korea, Republic of | Gachon University Gil Medical Center | Namdong-gu | Incheon-gwangyeoksi [Incheon] |
| Korea, Republic of | Seoul National University Bundang Hospital | Seongnam | Kyonggi-do |
| Korea, Republic of | Seoul National University Bundang Hospital | Seongnam | Kyonggi-do |
| Korea, Republic of | Asan Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Asan Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Kangbuk Samsung Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Korea University Anam Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Kyung Hee University Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Kyung Hee University Hospital at Gangdong | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Seoul National University Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Severance Hospital, Yonsei University Health System | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | The Catholic Univ. of Korea Seoul St. Mary's Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | The Catholic Univ. of Korea Seoul St. Mary's Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
| Korea, Republic of | Sejong General Hospital | Sosa-gu | Kyonggi-do |
| Korea, Republic of | The Catholic University Of Korea St. Vincent's Hospital | Suwon-si | Kyonggi-do |
| Korea, Republic of | Ulsan University Hospital | Ulsan | Ulsan-Kwangyokshi |
| Korea, Republic of | Yonsei University-Wonju Severance Christian Hospital | Wonju | Kang-won-do |
| Mexico | Centro de Investigación Cardiometabólica de Aguascalientes | Aguascalientes | |
| Mexico | Fundación Cardiovascular de Aguascalientes A.C. | Aguascalientes | |
| Mexico | Hospital Cardiologica Aguescalientes | Aguascalientes | |
| Mexico | Meander Medisch Centrum | Amersfoort | Utrecht |
| Mexico | Enclifar Ensayos Clínicos Farmacológicos Sc | Chihuahua | |
| Mexico | Centro Médico Nacional Siglo XXI | Ciudad de México | Distrito Federal |
| Mexico | Instituto de Diabetes, Obesidad y Nutricion | Cuernavaca | Morelos |
| Mexico | Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C. | Culiacan | Sinaloa |
| Mexico | Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia | Durango | |
| Mexico | CHRISTUS Centro de Excelencia en Investigación (Norte) | General Escobedo | Nuevo León |
| Mexico | Groene Hart Ziekenhuis | Gouda | Zuid-Holland |
| Mexico | Centro de Investigacion Medica Integral | Guadalajara | Jalisco |
| Mexico | CINVEC Medica | Guadalajara | Jalisco |
| Mexico | Diseno y Planeacion en Investigacion Medica | Guadalajara | Jalisco |
| Mexico | Instituto Jalisciense de Investigacion en Diabetes y Obesidad | Guadalajara | Jalisco |
| Mexico | Unidad de Investigación Clínica y Atención Médica HEPA | Guadalajara | Jalisco |
| Mexico | Virgen Cardiovascular Research SC | Guadalajara | Jalisco |
| Mexico | Investigación Médica Sonora, S.C. | Hermosillo | Sonora |
| Mexico | Instituto Cardiovascular de León S.C. | León | Guanajuato |
| Mexico | Medical Care and Research SA de CV | Merida | Yucatán |
| Mexico | Clinstile, S.A. de C.V. | Mexico | Distrito Federal |
| Mexico | Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares | Mexico City | Distrito Federal |
| Mexico | Clinica Omega | Mexico City | Distrito Federal |
| Mexico | Clínicos Asociados BOCM | Mexico City | Distrito Federal |
| Mexico | Grupo Medico Camino Sc | Mexico City | Distrito Federal |
| Mexico | Hospital de Jésus, I.A.P. | Mexico City | Distrito Federal |
| Mexico | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Mexico City | Distrito Federal |
| Mexico | ProcliniQ Investigación Clínica SA de CV | Mexico City | Distrito Federal |
| Mexico | RM Pharma Specialists | Mexico City | Distrito Federal |
| Mexico | Accelerium Clinical Research | Monterrey | Nuevo León |
| Mexico | Cardiolink Clin Trials | Monterrey | Nuevo León |
| Mexico | Centro de investigación y control metabólico | Monterrey | Nuevo León |
| Mexico | Clínica García Flores SC | Monterrey | Nuevo León |
| Mexico | Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey | Nuevo León |
| Mexico | Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey | Nuevo León |
| Mexico | Unidad biomedica avanzada monterrey | Monterrey | Nuevo León |
| Mexico | Clinica de Enfermedades Crónicas y de Procedimientos Especiales | Morelia | Michoacán |
| Mexico | Centro de Investigacion Clinica de Oaxaca | Oaxaca de Juarez | Oaxaca |
| Mexico | Centro de Estudios Clínicos de Querétaro (CECLIQ) | Querétaro | |
| Mexico | PanAmerican Clinical Research - Querétaro - Avenida Antea | Querétaro | |
| Mexico | Centro de Atención e Investigación Cardiovascular del Potosí | San Luis Potosí | |
| Mexico | Servicios Integrales Nova de Monterrey S.A. de C.V. | San Nicolas de los Garza | Nuevo León |
| Mexico | Centro de Investigacion Cardiovascular y Metabólica | Tijuana | Baja California |
| Mexico | Medimanage Research | Tlalpan | Distrito Federal |
| Mexico | Universitair Medisch Centrum Utrecht | Utrecht | |
| Mexico | Instituto Veracruzano en Investigación Clínica S.C. | Veracruz | |
| Mexico | Hospital Angeles Xalapa | Xalapa | Veracruz |
| Netherlands | Amsterdam UMC, locatie AMC | Amsterdam | Noord-Holland |
| Netherlands | Onze Lieve Vrouwe Gasthuis | Amsterdam | Noord-Holland |
| Netherlands | Gelre Ziekenhuis | Apeldoorn | Gelderland |
| Netherlands | Rode Kruis Ziekenhuis | Beverwijk | Noord-Holland |
| Netherlands | Reinier de Graaf Ziekenhuis, locatie Delft | Delft | Zuid-Holland |
| Netherlands | Jeroen Bosch ziekenhuis | Den Bosch | Noord-Brabant |
| Netherlands | Haga Ziekenhuis locatie Leyweg | Den Haag | Zuid-Holland |
| Netherlands | Deventer Ziekenhuis | Deventer | Overijssel |
| Netherlands | Slingeland Ziekenhuis | Doetinchem | Gelderland |
| Netherlands | Ziekenhuis Gelderse Vallei | Ede | Gelderland |
| Netherlands | Catharina Ziekenhuis | Eindhoven | Noord-Brabant |
| Netherlands | Admiraal de Ruyter Ziekenhuis, locatie Goes | Goes | Zeeland |
| Netherlands | General Practitioners Research Institute (GPRI) | Groningen | |
| Netherlands | Martini Ziekenhuis | Groningen | |
| Netherlands | Spaarne Gasthuis, Haarlem Zuid | Haarlem | Noord-Holland |
| Netherlands | Saxenburgh Medisch Centrum | Hardenberg | Overijssel |
| Netherlands | Ziekenhuis St. Jansdal | Harderwijk | Gelderland |
| Netherlands | Tergooiziekenhuizen, locatie Hilversum | Hilversum | Noord-Holland |
| Netherlands | Medische Centrum Leeuwarden | Leeuwarden | Fryslân |
| Netherlands | Leids Universitair Medisch Centrum | Leiden | Zuid-Holland |
| Netherlands | Radboudumc | Nijmegen | Gelderland |
| Netherlands | Bravis Ziekenhuis, locatie Roosendaal | Roosendaal | Noord-Brabant |
| Netherlands | Erasmus Medisch Centrum | Rotterdam | Zuid-Holland |
| Netherlands | Ikazia Ziekenhuis | Rotterdam | Zuid-Holland |
| Netherlands | Antonius Ziekenhuis, locatie D&A Research and Genetics | Sneek | Fryslân |
| Netherlands | ETZ TweeSteden | Tilburg | Noord-Brabant |
| Netherlands | Maxima Medisch Centrum, locatie Veldhoven | Veldhoven | Noord-Brabant |
| Netherlands | VieCuri Medisch Centrum, locatie Venlo | Venlo | Limburg |
| Netherlands | Zaans Medisch Centrum | Zaandam | Noord-Holland |
| Poland | Specderm Poznanska | Bialystok | Podlaskie |
| Poland | Polsko-Amerykanskie Kliniki Serca II Oddzial Kardiologiczny | Bielsko-Biala | Slaskie |
| Poland | INTERCOR | Bydgoszcz | Kujawsko-pomorskie |
| Poland | NZOZ Centrum Medyczne KERmed | Bydgoszcz | Kujawsko-pomorskie |
| Poland | Polsko-Amerykanskie Kliniki Serca PAKS Malopolskie Centrum Sercowo-Naczyniowe | Chrzanow | Malopolskie |
| Poland | Polsko-Amerykanskie Kliniki Serca | Dabrowa Gornicza | Slaskie |
| Poland | Centrum Kliniczno-Badawcze | Elblag | Warminsko-mazurskie |
| Poland | NZOZ TwojeZdrowie | Elblag | Warminsko-mazurskie |
| Poland | Uniwersyteckie Centrum Kliniczne | Gdansk | Pomorskie |
| Poland | Euromedica | Grudziadz | Kujawsko-pomorskie |
| Poland | NZOZ Salvia CM | Katowice | Slaskie |
| Poland | Polsko-Amerykanskie Kliniki Serca | Kedzierzyn-Kozle | Opolskie |
| Poland | Centrum Medyczne Linden | Krakow | Malopolskie |
| Poland | NZOZ Diab-Endo-Met | Krakow | Malopolskie |
| Poland | Poliklinika Kardiologiczna Serce | Leszno | Wielkopolskie |
| Poland | Centra Medyczne Medyceusz | Lodz | Lódzkie |
| Poland | Pro Salus Centrum Medyczne | Lodz | Lódzkie |
| Poland | Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi | Lódz | Lódzkie |
| Poland | 1 Wojskowy Szpital Kliniczny w Lublinie | Lublin | Lubelskie |
| Poland | CenterMed Lublin NZOZ | Lublin | Lubelskie |
| Poland | Clinical Best Solutions | Lublin | Lubelskie |
| Poland | Private Practice - Dr. Michal Tomaszewski | Lublin | Lubelskie |
| Poland | Wielospecjalistyczny Szpital Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Nowej Soli | Nowa Sol | Lubuskie |
| Poland | Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu | Przemysl | Podkarpackie |
| Poland | AKA-MED Centrum | Ruda Slaska | Slaskie |
| Poland | Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Zabówka E. Zabówka | Tarnow | Malopolskie |
| Poland | Polsko-Amerykanskie Kliniki Serca | Tychy | Slaskie |
| Poland | Balsam Medica | Warsaw | Mazowieckie |
| Poland | WIP Warsaw IBD Point Profesor Kierkus | Warsaw | Mazowieckie |
| Poland | Clinical Best Solutions | Warszawa | Mazowieckie |
| Poland | 4 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ | Wroclaw | Dolnoslaskie |
| Poland | NZOZ Centurm Medyczne SERAFIN-MED | Zarow | Dolnoslaskie |
| Puerto Rico | Advanced Clinical Research, LLC | Bayamón | |
| Puerto Rico | GCM Medical Group, PSC - Hato Rey Site | San Juan | |
| Romania | CMI DNBM Dr. Pop Lavinia | Baia Mare | Maramure? |
| Romania | Private Practice - Dr. Mercea Corina Delia | Baia Mare | Maramure? |
| Romania | C.M.D.T.A. Neomed | Brasov | |
| Romania | Centrul Medical Endocrinologie si Diabet Dr. Paveliu | Bucharest | Bucure?ti |
| Romania | Centrul Medical NutriLife | Bucharest | Bucure?ti |
| Romania | Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului | Bucharest | Bucure?ti |
| Romania | Nicodiab | Bucharest | Bucure?ti |
| Romania | Spitalul Universitar de Urgen?a Bucure?ti | Bucure?ti | |
| Romania | Mat Cord Biomedica S.R.L. | Buzau | Buzau |
| Romania | Spitalul Clinic Jude?ean de Urgen?a | Craiova | Dolj |
| Romania | Diamed Obesity | Gala?i | |
| Romania | Milena Sante | Gala?i | |
| Romania | Cardiomed Ia?i | Ia?i | |
| Romania | Centrul Medical Consultmed | Ia?i | |
| Romania | Clinica Korall | Satu Mare | |
| Romania | Policlinica Astra Sibiu | Sibiu | |
| Romania | Cardiomed | Târgu Mure? | Mure? |
| Romania | SC Dentosim Queen SRL - Centrul Medical Diamed | Târgu Mure? | Mure? |
| Romania | Centrul Medical Mediab | Târgu-Mure? | Mure? |
| Romania | Centrul Medical Mediab | Târgu-Mure? | Mure? |
| Romania | Private Practice - Dr. Cristian Podoleanu | Târgu-Mure? | Mure? |
| Romania | Institutul de Boli Cardiovasculare Timi?oara | Timi?oara | Timi? |
| Romania | Cabinet Medical Dr.Geru | Timisoara | Timi? |
| Slovakia | Cliniq s.r.o. | Bratislava | Bratislavský Kraj |
| Slovakia | ENDIAMED s.r.o | Dolny Kubin | Žilinský Kraj |
| Slovakia | JM-Interna s.r.o | Dolny Kubin | Žilinský Kraj |
| Slovakia | Human Care s.r.o. | Kosice | Košický Kraj |
| Slovakia | NEDÚ - Národný endokrinologický a diabetologický ústav n.o. | Lubochna | Žilinský Kraj |
| Slovakia | IN-DIA | Lucenec | Banskobystrický Kraj |
| Slovakia | Sin Azucar | Malacky | Bratislavský Kraj |
| Slovakia | AMBORA s.r.o. Interna ambulancia | Martin | Žilinský Kraj |
| Slovakia | Fakultná nemocnica Nitra | Nitra | Nitriansky Kraj |
| Slovakia | MEDIKALS | Pieštany | Trnavský Kraj |
| Slovakia | IMCORE | Presov | Prešovský Kraj |
| Slovakia | MEDISPOL | Presov | Prešovský Kraj |
| Slovakia | ENRIN, s.r.o. | Rimavská Sobota | Banskobystrický Kraj |
| Slovakia | Tatratrial s.r.o. | Rožnava | Košický Kraj |
| Slovakia | Areteus s.r.o. | Trebisov | Košický Kraj |
| Slovakia | MediPrax, s.r.o. | Trstena | Žilinský Kraj |
| Spain | CHUAC-Complejo Hospitalario Universitario A Coruña | A Coruña | A Coruña [La Coruña] |
| Spain | Hospital Universitario Fundacion ALcorcon | Alcorcón | Madrid, Comunidad De |
| Spain | Hospital Germans Trias i Pujol | Badalona | Barcelona [Barcelona] |
| Spain | Hospital Clínic de Barcelona | Barcelona | Catalunya [Cataluña] |
| Spain | Hospital de la Santa Creu i Sant Pau | Barcelona | Catalunya [Cataluña] |
| Spain | Parc de Salut Mar - Hospital del Mar | Barcelona | Barcelona [Barcelona] |
| Spain | Hospital Universitario Reina Sofia | Cordoba | Andalucía |
| Spain | Hospital de Denia Marina Salud | Dénia | Alicante |
| Spain | Hospital Clínico Universitario Virgen de la Arrixaca | El Palmar, Murcia | Murcia, Región De |
| Spain | Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval | Ferrol | A Coruña [La Coruña] |
| Spain | Hospital de Cabueñes | Gijón | Asturias |
| Spain | Hospital Universitari de Girona Doctor Josep Trueta | Girona | Girona [Gerona] |
| Spain | Hospital Unviersitario Virgen Nieves | Granada | Andalucía |
| Spain | Hospital Infanta Elena | Huelva | |
| Spain | Complejo Hospitalario de Jaén | Jaén | |
| Spain | Hospital Universitari de Bellvitge | L'Hospitalet de Llobregat | Catalunya [Cataluña] |
| Spain | Hospital Insular de Gran Canaria | Las Palmas de Gran Canaria | Las Palmas |
| Spain | Hospital Lucus Augusti | Lugo | |
| Spain | Hospital Clinico San Carlos | Madrid | |
| Spain | Hospital Universitario 12 de Octubre | Madrid | |
| Spain | Hospital Universitario La Paz | Madrid | |
| Spain | Hospital Universitario Ramón y Cajal | Madrid | Madrid, Comunidad De |
| Spain | Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | Madrid, Comunidad De |
| Spain | Hospital Universitario Virgen de la Victoria | Malaga | Andalucía |
| Spain | Hospital Universitari Son Espases | Palma | Balears [Baleares] |
| Spain | Hospital Universitario Quironsalud Madrid | Pozuelo de Alarcón | Madrid |
| Spain | Hospital Universitari Sant Joan de Reus | Reus | Tarragona [Tarragona] |
| Spain | Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca | Salamanca | |
| Spain | Hospital Virgen del Camino | Sanlúcar de Barrameda | Cádiz |
| Spain | Consorci Sanitari Integral. Hospital Moisés Broggi, Sant Joan Despí | Sant Joan Despí | Catalunya [Cataluña] |
| Spain | Hospital Universitario Marqués de Valdecilla | Santander | Cantabria |
| Spain | CHUS - Hospital Clinico Universitario | Santiago de Compostela | A Coruña [La Coruña] |
| Spain | Hospital General de Segovia | Segovia | |
| Spain | Hospital Universitario Virgen Del Rocio | Sevilla | |
| Spain | Hospital Universitario Virgen Macarena | Sevilla | |
| Spain | Vithas Hospital Sevilla | Seville | Sevilla |
| Spain | Hospital Arnau de Vilanova | Valencia | Valenciana, Comunitat |
| Spain | Hospital Clinico de Valencia | Valencia | Valenciana, Comunitat |
| Spain | Hospital General Universitario de Valencia | Valencia | València |
| Spain | Hospital Virgen de las Montañas | Villamartin | Cádiz |
| Spain | Hospital Universitario Miguel Servet | Zaragoza | |
| Taiwan | Changhua Christian Hospital | Changhua County | Changhua |
| Taiwan | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | |
| Taiwan | Chang Gung Memorial Hospital at Kaohsiung | Kaohsiung Niao Sung Dist | Kaohsiung |
| Taiwan | Fu Jen Catholic University Hospital | New Taipei | |
| Taiwan | Chung Shan Medical University Hospital | Taichung City | Taichung |
| Taiwan | National Cheng Kung University Hospital | Tainan | |
| Taiwan | Chi Mei Medical Center | Tainan City | Tainan |
| Taiwan | National Taiwan University Hospital | Taipei | |
| Taiwan | Taipei Medical University Hospital | Taipei | |
| Taiwan | Taipei Veterans General Hospital | Taipei | |
| Taiwan | Cathay General Hospital | Taipei City | Taipei |
| Taiwan | Shin Kong Wu Ho-Su Memorial Hospital | Taipei City | Taipei |
| Taiwan | Tri-Service General Hospital | Taipei City | Taipei |
| Taiwan | Chang Gung Medical Foundation-Linkou Branch | Taoyuan | |
| Taiwan | National Yang Ming Chiao Tung University Hospital | Yilan City | Yilan |
| United Kingdom | Bristol Royal Infirmary | Bristol | Bristol, City Of |
| United Kingdom | Panthera Biopartners - Glasgow | Glasgow | Scotland |
| United Kingdom | Hull and East Yorkshire Hospitals NHS Trust | Hull | Kingston Upon Hull |
| United Kingdom | Royal Free London NHS Foundation Trust | London | England |
| United Kingdom | Panthera Biopartners - Manchester | Rochdale | Manchester |
| United Kingdom | Salford Royal Hospital | Salford | Manchester |
| United Kingdom | Lister Hospital | Stevenage | Hertfordshire |
| United Kingdom | Torbay Hospital | Torquay | Devon |
| United Kingdom | Sunderland Royal Hospital | Tyne And Wear | |
| United Kingdom | Sandwell General Hospital | West Bromwich | |
| United States | American Clinical Trials - Acworth | Acworth | Georgia |
| United States | Golden Hearts Diagnostic | Alamogordo | New Mexico |
| United States | Albany Medical College, Division of Community Endocrinology | Albany | New York |
| United States | Albuquerque Neuroscience Inc. | Albuquerque | New Mexico |
| United States | Cambridge Medical Trials | Alexandria | Louisiana |
| United States | Lehigh Valley Health Network | Allentown | Pennsylvania |
| United States | Amarillo Heart Clinical Research Institute Inc. | Amarillo | Texas |
| United States | PharmaTex Research | Amarillo | Texas |
| United States | Alaska Heart and Vascular Institute | Anchorage | Alaska |
| United States | Atlanta Diabetes Associates | Atlanta | Georgia |
| United States | Emory University School of Medicine | Atlanta | Georgia |
| United States | Grady Memorial System | Atlanta | Georgia |
| United States | Southeastern Clinical Research Institute | Augusta | Georgia |
| United States | University of Colorado Anschutz Medical Campus | Aurora | Colorado |
| United States | IMA Clinical Research Austin | Austin | Texas |
| United States | Velocity Clinical Research, Austin | Austin | Texas |
| United States | American Health Network of IN, LLC | Avon | Indiana |
| United States | Care Access - Baltimore | Baltimore | Maryland |
| United States | Maryland Cardiovascular Specialists | Baltimore | Maryland |
| United States | MedStar Good Samaritan Hospital | Baltimore | Maryland |
| United States | Sinai Hospital Of Baltimore | Baltimore | Maryland |
| United States | Rapid Medical Research | Beachwood | Ohio |
| United States | Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania |
| United States | Jadestone Clinical Research | Beltsville | Maryland |
| United States | Westside Medical Associates of Los Angeles | Beverly Hills | California |
| United States | The National Diabetes & Obesity Research Institute | Biloxi | Mississippi |
| United States | Birmingham Clinical Research | Birmingham | Alabama |
| United States | Excel Medical Clinical Trials | Boca Raton | Florida |
| United States | Care Research | Boise | Idaho |
| United States | Grace Research - Bossier | Bossier City | Louisiana |
| United States | Brigham and Women's Hospital Diabetes Program | Boston | Massachusetts |
| United States | Flourish Research - Bowie | Bowie | Maryland |
| United States | Qualmedica Research | Bowling Green | Kentucky |
| United States | Bridgeport Hospital | Bridgeport | Connecticut |
| United States | Internal Medicine Associates | Bridgeton | New Jersey |
| United States | Headlands Research - Brownsville | Brownsville | Texas |
| United States | Mercury Street Medical Group, PLLC | Butte | Montana |
| United States | Capital Area Research, LLC | Camp Hill | Pennsylvania |
| United States | East Coast Institute for Research - Canton | Canton | Georgia |
| United States | Accellacare Trident Cardiology | Charleston | South Carolina |
| United States | Chicago Clinical Research Institute | Chicago | Illinois |
| United States | Velocity Clinical Research, Mt. Auburn | Cincinnati | Ohio |
| United States | Velocity Clinical Research, Springdale | Cincinnati | Ohio |
| United States | Clearwater Cardiovascular & Interventional Consultants M.D., P.A. | Clearwater | Florida |
| United States | Clinical Research of West Florida, Inc. (Clearwater) | Clearwater | Florida |
| United States | Cleveland Clinic | Cleveland | Ohio |
| United States | Alpine Research Organization | Clinton | Utah |
| United States | Kur Research - Columbia Medical | Columbia | Maryland |
| United States | Aventiv Research Inc | Columbus | Ohio |
| United States | Ohio State University | Columbus | Ohio |
| United States | South Texas Clinical Research | Corpus Christi | Texas |
| United States | Good Samaritan Regional Medical Center | Corvallis | Oregon |
| United States | Valley Clinical Trials, Inc. | Covina | California |
| United States | Baylor Soltero CV Research Center | Dallas | Texas |
| United States | Cedar Health Research | Dallas | Texas |
| United States | Private Practice - Dr. James E. Race | Dallas | Texas |
| United States | UT Southwestern Medical Center | Dallas | Texas |
| United States | Zenos Clinical Research | Dallas | Texas |
| United States | Alliance for Multispecialty Research, LLC | Daphne | Alabama |
| United States | Alliance for Multispecialty Research, LLC. | Dearborn | Michigan |
| United States | Revival Research Institute - Dearborn | Dearborn | Michigan |
| United States | Cardio Voyage | Denison | Texas |
| United States | Care Access - Dorchester | Dorchester | Massachusetts |
| United States | SEC Clinical Research | Dothan | Alabama |
| United States | American Clinical Trials - Douglasville | Douglasville | Georgia |
| United States | South Texas Research Institute | Edinburg | Texas |
| United States | Neighborhood Healthcare Institute of Health | Escondido | California |
| United States | NECCR PrimaCare Research | Fall River | Massachusetts |
| United States | Virginia Heart | Falls Church | Virginia |
| United States | Care Access - Fayetteville | Fayetteville | North Carolina |
| United States | Anderson Medical Research | Fort Washington | Maryland |
| United States | Texas Health Research & Education Institute - Fort Worth | Fort Worth | Texas |
| United States | HB Clinical Trials - Fountain Valley | Fountain Valley | California |
| United States | American Health Network of IN, LLC | Franklin | Indiana |
| United States | Center for Advanced Research & Education | Gainesville | Georgia |
| United States | Mercy Gilbert Medical Center | Gilbert | Arizona |
| United States | Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC | Gilbert | Arizona |
| United States | Medication Management | Greensboro | North Carolina |
| United States | Triad Clinical Trials | Greensboro | North Carolina |
| United States | Physician's East Endocrinology | Greenville | North Carolina |
| United States | Tribe Clinical Research, LLC | Greenville | South Carolina |
| United States | Medi-Lab Diagnostic | Gulfport | Mississippi |
| United States | Clinical Investigation Specialists | Gurnee | Illinois |
| United States | Hartford Hospital (HH) | Hartford | Connecticut |
| United States | Las Vegas Endocrinology | Henderson | Nevada |
| United States | Elite Cardiac Research Center | Hialeah | Florida |
| United States | The Queen's Medical Center | Honolulu | Hawaii |
| United States | Abington Medical Specialists | Horsham | Pennsylvania |
| United States | Amir A Hassan, MD, PA | Houston | Texas |
| United States | Center for Cardiometabolic Disease Prevention/Baylor College of Medicine | Houston | Texas |
| United States | Endocrine Ips, Pllc | Houston | Texas |
| United States | Juno Research | Houston | Texas |
| United States | Accurate Clinical Research, Inc | Humble | Texas |
| United States | Care Access Research - Huntington Beach | Huntington Beach | California |
| United States | MedStar Health Research Institute (MedStar Physician Based Research Network) | Hyattsville | Maryland |
| United States | Indiana University Health Methodist Hospital | Indianapolis | Indiana |
| United States | 310 Clinical Research | Inglewood | California |
| United States | Encore Research Group- Jacksonville Center for Clinical Research | Jacksonville | Florida |
| United States | Westside Center for Clinical Research | Jacksonville | Florida |
| United States | Clinical Investigation Specialists | Kenosha | Wisconsin |
| United States | Marian David, MD, P.C. | Kew Gardens | New York |
| United States | Alliance for Multispecialty Research, LLC | Knoxville | Tennessee |
| United States | Scripps Whittier Diabetes Institute | La Jolla | California |
| United States | UCSD - Altman Clinical and Translational Research Institute (ACTRI) | La Jolla | California |
| United States | Care Access - Lake Charles | Lake Charles | Louisiana |
| United States | Long Island Cardiovascular Consultants | Lake Success | New York |
| United States | First Valley Medical Group | Lancaster | California |
| United States | Lancaster General Hospital | Lancaster | Pennsylvania |
| United States | Clearwater Cardiovascular & Interventional Consultants M.D., P.A. | Largo | Florida |
| United States | DaVita Clinical Research - Las Vegas | Las Vegas | Nevada |
| United States | Las Vegas Medical Research | Las Vegas | Nevada |
| United States | Palm Research Center Tenaya | Las Vegas | Nevada |
| United States | Georgia Clinical Research - Lawrenceville | Lawrenceville | Georgia |
| United States | Walker Family Care | Little River | South Carolina |
| United States | Cardiology and Medicine Clinic | Little Rock | Arkansas |
| United States | Ark Clinical Research | Long Beach | California |
| United States | MemorialCare Health System - Long Beach Medical Center | Long Beach | California |
| United States | Cardiovascular Research Foundation of Southern California | Los Angeles | California |
| United States | Keck School of Medicine of USC | Los Angeles | California |
| United States | The Heart Institute of East Texas | Lufkin | Texas |
| United States | East Coast Institute for Research at The Jones Center | Macon | Georgia |
| United States | K2 Medical Research - Maitland | Maitland | Florida |
| United States | South Florida Clinical Research Institute | Margate | Florida |
| United States | Care Access - Mauldin | Mauldin | South Carolina |
| United States | Biopharma Informatic, LLC | McAllen | Texas |
| United States | North Texas Research Associates | McKinney | Texas |
| United States | Texas Institute of Cardiology, PA | McKinney | Texas |
| United States | Wellness Clinical Research | McKinney | Texas |
| United States | Care Access - Memphis | Memphis | Tennessee |
| United States | PRX Research | Mesquite | Texas |
| United States | Southern Endocrinology Associates | Mesquite | Texas |
| United States | Suncoast Research Group | Miami | Florida |
| United States | Inpatient Research Clinic | Miami Lakes | Florida |
| United States | Alliance for Multispecialty Research, LLC | Mobile | Alabama |
| United States | Mobile Heart Specialists | Mobile | Alabama |
| United States | IMA Clinical Research | Monroe | Louisiana |
| United States | Exemplar Research | Morgantown | West Virginia |
| United States | IMA Clinical Research Mount Airy | Mount Airy | North Carolina |
| United States | Accellacare - Mt Pleasant | Mount Pleasant | South Carolina |
| United States | Intermountain Medical Center | Murray | Utah |
| United States | Advanced Research for Health Improvement, LLC | Naples | Florida |
| United States | Alliance for Multispecialty Research, LLC | New Orleans | Louisiana |
| United States | Icahn School of Medicine at Mount Sinai | New York | New York |
| United States | IMA Clinical Research | New York | New York |
| United States | Lenox Hill Hospital | New York | New York |
| United States | NYU Langone Health | New York | New York |
| United States | NYU Langone Health | New York | New York |
| United States | Alliance for Multispecialty Research, LLC | Norfolk | Virginia |
| United States | Renstar Medical Research | Ocala | Florida |
| United States | Elixia Central Florida | Orlando | Florida |
| United States | Florida Institute For Clinical Research, LLC | Orlando | Florida |
| United States | Desert Oasis Healthcare Medical Group | Palm Springs | California |
| United States | Alliance for Multispecialty Research, LLC | Park Ridge | Illinois |
| United States | AMZERN Clinical Trial Organization | Peoria | Arizona |
| United States | Clinical Research of Philadelphia | Philadelphia | Pennsylvania |
| United States | Penn Medicine: University of Pennsylvania Health System | Philadelphia | Pennsylvania |
| United States | Absolute Clinical Research | Phoenix | Arizona |
| United States | Elite Clinical Studies | Phoenix | Arizona |
| United States | Helios Clinical Research - Phoenix | Phoenix | Arizona |
| United States | AHN Allegheny General Hospital | Pittsburgh | Pennsylvania |
| United States | Keystone Clinical Studies | Plymouth Meeting | Pennsylvania |
| United States | Innovative Research Institute - Port Charlotte | Port Charlotte | Florida |
| United States | Peace River Cardiovascular Center | Port Charlotte | Florida |
| United States | Progressive Medical Research | Port Orange | Florida |
| United States | Accellacare - Raleigh | Raleigh | North Carolina |
| United States | Monument Health Rapid City Hospital | Rapid City | South Dakota |
| United States | Eastside Research Associates | Redmond | Washington |
| United States | Northwell Health Physician Peconic | Riverhead | New York |
| United States | University of Rochester Medical Center | Rochester | New York |
| United States | Clearwater Cardiovascular & Interventional Consultants M.D., P.A. | Safety Harbor | Florida |
| United States | StudyMetrix Research | Saint Peters | Missouri |
| United States | Clinical Advancement Center | San Antonio | Texas |
| United States | Clinical Trials of Texas, Inc. | San Antonio | Texas |
| United States | Diagnostics Research Group | San Antonio | Texas |
| United States | Endeavor Clinical Trials | San Antonio | Texas |
| United States | Artemis Institute for Clinical Research | San Diego | California |
| United States | Care Access - Santa Clarita | Santa Clarita | California |
| United States | Saratoga Clinical Research | Saratoga Springs | New York |
| United States | Consano Clinical Research, LLC | Shavano Park | Texas |
| United States | DaVita Clinical Research - North Houston | Shenandoah | Texas |
| United States | Revival Research Institute - Sherman | Sherman | Texas |
| United States | Sherman Clinical Research | Sherman | Texas |
| United States | Millennium Clinical Trials | Simi Valley | California |
| United States | Louisiana Heart Center - Slidell | Slidell | Louisiana |
| United States | Cardio Metabolic Institute | Somerset | New Jersey |
| United States | Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois |
| United States | Cardiology Associates of Fairfield County, P.C. | Stamford | Connecticut |
| United States | Stanford University Medical Center | Stanford | California |
| United States | Stony Brook University | Stony Brook | New York |
| United States | Atlantic Health System Overlook Medical Center | Summit | New Jersey |
| United States | Clinical Research Institute of Arizona (CRI) - Sun City West | Sun City West | Arizona |
| United States | Olive View-UCLA Medical Center | Sylmar | California |
| United States | Care Access - Tampa | Tampa | Florida |
| United States | Clinical Research of West Florida | Tampa | Florida |
| United States | Care Access - Thousand Oaks | Thousand Oaks | California |
| United States | Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc. | Toluca Lake | California |
| United States | Cotton O'Neil Clinical Research Center - Central Office | Topeka | Kansas |
| United States | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California |
| United States | UCLA South Bay Endocrinology | Torrance | California |
| United States | Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan |
| United States | Eclipse Clinical Research | Tucson | Arizona |
| United States | Synexus Clinical Research US, Inc./Orange Grove Family Practice | Tucson | Arizona |
| United States | Preferred Primary Care Physicians | Uniontown | Pennsylvania |
| United States | InvivoCure | Van Nuys | California |
| United States | Synexus Clinical Research US - Vista | Vista | California |
| United States | IMA Clinical Research Warren | Warren | New Jersey |
| United States | MedStar Washington Hospital Center | Washington | District of Columbia |
| United States | Chase Medical Research, LLC | Waterbury | Connecticut |
| United States | Cardiology Partners Clinical Research Institute - Wellington | Wellington | Florida |
| United States | Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa |
| United States | Interventional Cardiology Medical Group | West Hills | California |
| United States | Accellacare - Wilmington | Wilmington | North Carolina |
| United States | Accellacare - DuPage | Winfield | Illinois |
| United States | Wake Forest Baptist Health | Winston-Salem | North Carolina |
| United States | Cardiology Consultants of Philadelphia Yardley | Yardley | Pennsylvania |
| United States | Heart and Vascular Research at WellSpan Health | York | Pennsylvania |
| United States | Michigan Heart & Vascular Institute | Ypsilanti | Michigan |
| Lead Sponsor | Collaborator |
|---|---|
| Eli Lilly and Company |
United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Czechia, Denmark, France, Germany, Greece, Hungary, India, Israel, Italy, Japan, Korea, Republic of, Mexico, Netherlands, Poland, Puerto Rico, Romania, Slovakia, Spain, Taiwan, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Time to First Occurrence of Any Component of the Major Adverse Cardiac Event (MACE)-4 Composite Endpoint | Time to first event in a MACE-4 composite endpoint, comprised of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and urgent coronary revascularization. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Change from Baseline in Lipoprotein(a) [Lp(a)] at Week 4 | Change from Baseline in Lp(a) | Baseline, Week 4 | |
| Secondary | Time to First Occurrence of Any of the Component of MACE-3 Composite Endpoint | Time to first occurrence MACE-3 | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to First Occurrence of Fatal or Non-Fatal Myocardial Infarction | Time to first occurrence of fatal or non-fatal myocardial infarction. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to Cardiovascular Death | Time to cardiovascular death. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to Occurrence of All-Cause Death | Time to occurrence of all-cause death | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to First Occurrence of Any Component of the MACE-4 Composite Endpoint (In the Population with Established ASCVD and CV Event, or Revascularization) | Time to first occurrence of any component of the MACE-4 composite endpoint. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population At Risk for First CV event) | Time to first occurrence of any component of the MACE-4 composite endpoint. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population with Lp(a) = 200 nmol/L) | Time to first occurrence of any component of the MACE-4 composite endpoint. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to First Occurrence of Any Component of MACE-3 + MALE Composite Endpoint | Time to first occurrence of any component of MACE-3 + MALE composite endpoint. | Baseline up to End of Study (About 4.5 Years) | |
| Secondary | Time to First Occurrence of Any Component of Coronary MACE-3 Composite Endpoint | Time to first Occurrence of any component of coronary MACE-3 composite endpoint. | Baseline up to End of Study (About 4.5 Years) |