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Dysgeusia clinical trials

View clinical trials related to Dysgeusia.

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NCT ID: NCT06384365 Recruiting - Taste, Altered Clinical Trials

Interaction of Inflammation, Taste Perception and Preferences as a Function of Physical Activity and Body Composition

Start date: April 15, 2024
Phase:
Study type: Observational

The aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity. The focus will be on sweet taste and the perception of fat. A non-invasive, observational study design will be used.

NCT ID: NCT06311877 Not yet recruiting - Dysgeusia Clinical Trials

Effects of Flavor Modification for Management of Radiation Induced Dysgeusia

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

Intervention for dysgeusia in head and neck cancer patients undergoing radiation therapy. This research proposal aims to investigate potential benefits of mBerry in improving quality of life and nutritional outcome in head and neck cancer patients' post-radiation therapy. Our hypothesis is that cancer patients undergoing radiation therapy will benefit from use of miracle berry in treatment of dysgeusia.

NCT ID: NCT06291337 Completed - Clinical trials for Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants

Ibuprofen Inhibits Human Sweet Taste

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism. Recently, ibuprofen and naproxen have been identified to inhibit human T1R3 when heterologously expressed in cells. In the present study, the initial objective was to determine if ibuprofen and naproxen inhibit interactions of sugars with human sweet taste receptor under normal, physiological conditions. Ten healthy participants were asked to rate sweetness intensity for a range of sweet stimuli (sucrose, fructose, sucralose) after a prerinse of ibuprofen, naproxen or water. Both ibuprofen and naproxen inhibited sweet taste intensity in a dose-dependent manner. In association studies, ibuprofen use has been linked to preserved metabolic function, as its use is correlated with lower rates of Alzheimer's disease, diabetes and colon cancer. Here the investigators present a potential novel pathway for systemic ibuprofen to impact these metabolic diseases.

NCT ID: NCT06287294 Recruiting - Neoplasms Clinical Trials

An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer

Start date: August 30, 2023
Phase:
Study type: Observational

Taste problems and xerostomia (dry mouth) are common among patients with advanced cancer. These symptoms can affect the pleasure of eating and drinking, reduce dietary intake, cause low mood, and a lower quality of life. This study will explore the relationship between dry mouth and taste problems in patients with advanced cancer.

NCT ID: NCT06251050 Not yet recruiting - Clinical trials for Head and Neck Squamous Cell Carcinoma

A Lithium-containing Mouthwash Prevention and Treatment of Oral Mucositis and Dysgeusia in Patients Undergoing Radiotherapy

Start date: March 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

To evaluate the efficacy and safety of lithium-containing mouthwash for prevention and treatment of oral mucositis and dysgeusia in patients undergoing radiotherapy for malignant head and neck tumors.

NCT ID: NCT06103422 Completed - Clinical trials for Orthognathic Surgery

Change in Taste Sensation After Orthognathic Surgery

Start date: July 17, 2020
Phase: N/A
Study type: Interventional

Orthognathic surgery refers to jaw operations that can be performed on the upper jaws (Le Fort I osteotomy) and lower jaws (Sagittal Split Ramus osteotomy). In orthognathic surgery practice, taste perception could be affected by potential damage to peripheral nerves that conduct chemosensory information regarding gustation from the palate and tongue. This study aimed to evaluate the changes in the sense of taste after Le Fort I osteotomy, Sagittal Split Ramus osteotomy, and bimaxillary surgery.

NCT ID: NCT06089993 Completed - Exercise Clinical Trials

Impact of Acute Resistance Exercise on Taste Perception and Appetite Response to Plant Protein in Resistance Trained Adults

Start date: August 8, 2022
Phase: N/A
Study type: Interventional

Some evidence suggests that taste perception might be modulated by physical exercise, with differences observed after aerobic exercise (DOI:10.1093/chemse/23.4.417) and with habitual exercise (DOI:10.3390/nu11010155). However, the effects of resistance exercise on taste perception has not been studied. This knowledge is important as it may impact the acceptability of foods consumed after exercise. While plant-protein supplement powders are gaining increased popularity, their palatability and, thereby, acceptability may be a shortcoming. This randomised crossover trial aims to investigate (1) the taste perception and acceptability of plant protein supplement powders and (2) whether resistance exercise modulates taste perception and appetite responses to plant protein.

NCT ID: NCT05868850 Completed - Chemotherapy Effect Clinical Trials

Application of Auricular Point Sticking in Patients With Taste Alteration

Start date: June 3, 2023
Phase: N/A
Study type: Interventional

To explore the intervention effect of auricular point sticking on chemotherapy-induced taste alterations in cancer patients, and analyze its relationship with quality of life, nutritional status and psychology of patients.

NCT ID: NCT05819073 Completed - Saliva Altered Clinical Trials

Astringency and Oral Health

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

The perception of astringency is thought to involve the interaction between tannins and salivary proteins. However, the mechanisms underlying this interaction are poorly understood. The tannins' subclass known as type A proanthocyanidins seems to have a positive effect on human health. Despite that, humans show large individual differences in the sensory perception and acceptance of astringent foods such as tea, wine and chocolate suggesting that this variation may have a genetic basis. Salivary proteins play an essential role both in affecting oral taste perception and in maintaining a healthy oral environment. Diverse microorganisms inhabit the oral cavity. The interactions between oral microbiota, host and environmental factors influence microbial homeostasis and ultimately human oral health. Understanding individual differences in salivary proteins, oral microbiome and the mechanisms by which tannins evoke the perception of astringency could provide important insights into the role of these compounds in human nutrition and health.

NCT ID: NCT05812209 Completed - Pain Clinical Trials

Stellate Ganglion Block to Treat Long COVID 19 Case Series

Start date: September 1, 2022
Phase:
Study type: Observational

An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.