Clinical Trials Logo

Disorders of Consciousness clinical trials

View clinical trials related to Disorders of Consciousness.

Filter by:
  • Completed  
  • Page 1 ·  Next »

NCT ID: NCT06403176 Completed - Clinical trials for Transient Ischemic Attack

Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

Start date: May 1, 2022
Phase:
Study type: Observational [Patient Registry]

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

NCT ID: NCT06014476 Completed - Clinical trials for Psychological Distress

Psychological Symptoms and Burden in Caregivers of Patients With Disorders of Consciousness

Start date: August 1, 2021
Phase:
Study type: Observational

Caregivers of patients with disorders of consciousness are highly prone to developing mental health issues. The aim of this study is to investigate the psychological symptoms and care burden of caregivers of patients with disorders of consciousness (DoC), and to examine which characteristics of patients were burden predictors to caregivers.

NCT ID: NCT04330547 Completed - Clinical trials for Minimally Conscious State

Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.

Start date: February 21, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC). This project is divided into two phases, a first phase to evaluate pain level and a second phase which consist of a clinical trial to evalute pain medication efficacy. The main aim is to evaluate the use of the Nociception Coma Scale-Revised (NCS-R) and its cut-off score (i.e., 5) as an assessment and management tool to define guidelines for managing pain in patients with DOC. In this double-blind, placebo-controlled clinical study, we will evaluate the use of analgesic treatments in reducing pain in subacute/chronic patients. The project will also allow us to validate the NCS-R cut-off score defined previously.

NCT ID: NCT03115021 Completed - Clinical trials for Disorders of Consciousness

Neurophysiological Effects of tPCS and tDCS on Patients With Disorders of Consciousness

Start date: May 1, 2018
Phase: Phase 1
Study type: Interventional

This study aims at comparing the effects of transcranial direct current stimulation and transcranial pulsed current stimulation on neurophysiological outcomes on patients with disorders of consciousness. This study also aims to evaluate the effects of these techniques on patients' level of consciousness.

NCT ID: NCT02930213 Completed - Clinical trials for Disorders of Consciousness

The Core Body Temperature Rhythms: Distinguishing MCS From UWS

Start date: January 2015
Phase: Phase 2
Study type: Observational [Patient Registry]

In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .

NCT ID: NCT02879565 Completed - Clinical trials for Disorders of Consciousness

Families Expectations and Hope Raised by an Evaluation of Consciousness in Patients in a Vegetative State

REVE
Start date: September 2011
Phase: N/A
Study type: Interventional

Progress in resuscitation has increased the chances of survival after anoxic or traumatic brain injury. More and more patients with severe cerebral damages are resuscitated but upon awakening from coma, some patients remain in a state which cannot be qualified as conscious and is now known as an unresponsive wakefulness syndrome (UWS; formerly known as vegetative state). This condition can be transitory and evolve towards recovery, or remain chronic and lasting for years. To improve the diagnosis of patients with disorders of consciousness, recent advances in brain imaging have led to the development of new methods of detecting awareness. In the absence of overt behavioral responses from these patients, imaging-based diagnostic methods have been first used to assess whether some cerebral areas were preserved in UWS patients and showed an activation of the primary sensory cortices in some UWS patients, whether it occurs at the auditory, visual or somatosensory level. Unavoidable technical and ethical issues are raised for clinicians before responding to such requests: 1. Is it technically possible to generalize neuroimaging protocols to all healthcare institutions? 2. Is it ethically acceptable to propose neuroimaging protocols without an accurate estimation of their psychological impact on families and caregivers? The present study aims to understand and anticipate the technical and ethical issues related to an evaluation of consciousness with functional neuroimaging. How the evaluation of awareness in a patient affects the caregivers and family members will be investigated. By using qualitative research hopes and expectations will be clarified through the experiences of families, clinicians and nurses faced to this situation. Will be included in this research professional caregivers and persons closely related to UWS patients: - Family members or close circle visiting the patients on a regular basis - Referring clinicians - Nurses in charge of the patients' care This prospective study uses qualitative, interview-based, research. Two key-moments are explored in succession to examine the impact of a neuroimaging evaluation of consciousness in institutionalized UWS patients: - interviews of professional caregivers and families about their hopes concerning the evaluation of consciousness of UWS patients, - interviews of professional caregivers and families about the impact of evaluating consciousness on their beliefs

NCT ID: NCT02759068 Completed - Clinical trials for Disorders of Consciousness

Beneficial Effects of Preference on Behavior in DOC Patients (COGNICOMA)

COGNICOMA
Start date: November 2014
Phase: N/A
Study type: Interventional

Preferred music improves cognitive function in patients with disorders of consciousness (DOC). However, it is still unknown whether it is a general effect of music (because of its acoustic features) or an autobiographical effect (because of its emotional and meaningful contents). The aim of the present study was to investigate the effect of sensory modality (auditory versus olfactory) and preference (preferred versus neutral) of the testing context on the performance of four items from the coma recovery scale-revised

NCT ID: NCT02639481 Completed - Brain Injuries Clinical Trials

Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness

EriCOS
Start date: January 2016
Phase: Phase 3
Study type: Interventional

Patients with acquired brain injury (ABI) often suffer from severe disorders of consciousness (DOC), such as coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS). This study examines the effect, a novel robotic rehabilitation device (the Erigo®Pro system) has on the recovery of consciousness of DOC patients. The device enables patients to be verticalized very early during acute neurorehabilitation and includes robotic leg movement training as well as functional electrical stimulation (FES) of leg nerves. Patients will be randomly allocated to one of three treatment groups: (i) control group with standard physiotherapy without the device, (ii) device treatment without FES, and (iii) device treatment with FES. Time until recovery of consciousness, rehabilitation outcome, and amount of complications will be the outcome variables.

NCT ID: NCT02626403 Completed - Clinical trials for Minimally Conscious State

Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness

Start date: January 2015
Phase: N/A
Study type: Interventional

Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention. In severely brain injured patients with disorders of consciousness (DOC), a single stimulation over the left dorsolateral prefrontal cortex has shown to improve patients' sign of consciousness. Nevertheless, other brain areas could be stimulated in order to increase the number of responders. In this study, investigators will assess the effects of bilateral fronto-parietal tDCS on Coma Recovery Scale-Revised (CRS-R) scores in patients with DOC in a double-blind sham-controlled experimental design.

NCT ID: NCT02424656 Completed - Clinical trials for Traumatic Brain Injury

Alterations in the Brain's Connectome After Severe Traumatic Brain Injury

ABCinTBI
Start date: September 2014
Phase:
Study type: Observational

This study explores the changes in whole-brain connectivity that occur during recovery from severe Traumatic Brain Injury and how these changes are related to the recovery of consciousness. Multimodal neuroimaging techniques will be used in a longitudinal fashion while patients are undergoing neurorehabilitation and after one-year of the TBI episode.