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Discogenic Pain clinical trials

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NCT ID: NCT06372054 Recruiting - Clinical trials for Cardiovascular Risk Factor

TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models

Start date: February 5, 2024
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to define a personalized risk model in the super healthy and homogeneous population of Italian Air Force high-performance pilots. This peculiar cohort conducts dynamic activities in an extreme environment, compared to a population of military people not involved in flight activity. The study integrates the analyses of biological samples (urine, blood, and saliva), clinical records, and occupational data collected at different time points and analyzed by omic-based approaches supported by Artificial Intelligence. Data resulting from the study will clarify many etiopathological mechanisms of diseases, allowing the creation of a model of analyses that can be extended to the civilian population and patient cohorts for the potentiation of precision and preventive medicine.

NCT ID: NCT06349226 Recruiting - Clinical trials for Intervertebral Disc Degeneration

Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic Pain

Start date: May 22, 2018
Phase:
Study type: Observational

Low back pain, associated with intrinsic disorders of the spine, is a very frequent clinical condition that is accompanied by high morbidity with effects both on psychosocial aspects, and health care system. It occurs in approximately 80% of the population throughout their lives. Most low back pain is associated with intervertebral disc degeneration (IDD) associated with neuroinflammation and pain. In this context, the study of sphingolipid metabolism can play an important role in the identification of new molecules responsible for the degenerative process. Sphingolipids, in fact, are a class of molecules that are implicated in multiple signal pathways, such as proliferation, degradation of the extracellular matrix, inflammatory state, apoptosis and migration. In particular, sphingosine-1-phosphate (S1P), an intermediate of sphingolipid metabolism, acts as a pro-inflammatory mediator, predominantly in the extracellular environment, regulating important cellular properties related to inflammatory potential and pain. The objective of this study is to characterize the degenerative process in cells isolated from degenerated human intervertebral discs from both at cellular and molecular levels in order to identify new targets implicated in degenerative processes, including sphingolipid signaling pathway.

NCT ID: NCT06345690 Recruiting - Back Pain Clinical Trials

VIA Disc NP Registry 3.0

Start date: February 27, 2024
Phase:
Study type: Observational [Patient Registry]

Registry is to observe and trend patterns of care and outcomes for patients treated with VIA Disc NP.

NCT ID: NCT06127745 Not yet recruiting - Clinical trials for Degenerative Disc Disease

Discure Technologies Feasibility Study for DDD

Start date: January 2024
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the safety and performance of the Discure System therapy in subjects with early to moderate degeneration of the disc (DDD).

NCT ID: NCT05969392 Not yet recruiting - Discogenic Pain Clinical Trials

Evaluation of Efficacy and Safety of Intradiscal Gelified Ethanol in Refractory Cervical Discogenic Pain

DISCERV
Start date: October 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to assesse safety and efficacy of the Intradiscal Gelified Ethanol for treatment in refractory cervical discogenic pain.

NCT ID: NCT05610553 Not yet recruiting - Low Back Pain Clinical Trials

Application of 3D Printing Guide Plate in Percutaneous Disc Decompression

Start date: December 10, 2022
Phase: N/A
Study type: Interventional

Application of 3D printing guide plate in percutaneous disc decompression

NCT ID: NCT04727385 Recruiting - Clinical trials for Degenerative Disc Disease

Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease

DXM gel
Start date: September 15, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and the efficacy of an hydrogel (double cross-link microgel - DXM) injection into the intervertebral disc (IVD) space in patients with painful lumbar degenerative disc disease (DDD) over 24 to 48 weeks.

NCT ID: NCT04673461 Active, not recruiting - Discogenic Pain Clinical Trials

Study Investigating STA363 Compared to Placebo in Patients With Chronic Discogenic Low Back Pain

STA-02
Start date: July 31, 2020
Phase: Phase 2
Study type: Interventional

This is a phase IIb, prospective, multi-country, multicenter, randomized, double-blind, placebo-controlled, parallel group study to investigate the efficacy, safety and transformation of NP following single intradiscal injection of STA363 (lactic acid) into one or two IVDs compared to placebo for the treatment of discogenic low back pain. This study will be conducted in Russia, Spain and the Netherlands.

NCT ID: NCT04652687 Terminated - Back Pain Clinical Trials

VIA Disc NP Registry

Start date: May 3, 2020
Phase:
Study type: Observational [Patient Registry]

Registry is to observe and trend patterns of care and outcomes for patients treated with VIA Disc NP.

NCT ID: NCT04544709 Terminated - Chronic Pain Clinical Trials

Intradiscal Platelet Rich Plasma

Start date: February 14, 2019
Phase: Phase 4
Study type: Interventional

To assess changes in pain and function in patients with discogenic low back pain after a standard of care intradiscal injection of Platelet-Rich Plasma (PRP).