Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis

Dilated Cardiomyopathy Clinical Trial

— DESMIN  

Official title:

Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT00819442
• Other study ID #: N N402196135
• Status: Not yet recruiting
• Phase: N/A
• First received: January 8, 2009
• Last updated: January 8, 2009
• Start date: January 2009
• Est. completion date: June 2011

Study information

• Verified date: January 2009
• Source: Ministry of Scientific Research and Information Technology, Poland
• Contact: Agnieszka Pawlak, PhD
• Phone: +48502133158
• Email: a.pawlak1[@]wp.pl
• Is FDA regulated: No
• Health authority: Poland: Ministry of Science and Higher Education
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is evaluation of expression of desmin in cardiomyocytes of patients with idiopathic dilated cardiomyopathy. Analysis of relationship between desmin expression and activities of mitochondrium and expression of ubiquitin.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: June 2011
• Est. primary completion date: January 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• idiopatic dilated cardiomyopathy, NYHA I, II, III, IV

• dilated left ventricle

• ejection fraction below 45%

Exclusion Criteria:

• diabetes mellitus

• kidney failure (GFR < 30, creatinine below 2,5 mg/dl

Study Design

Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Cardiomyopathies
• Cardiomyopathy, Dilated
• Dilated Cardiomyopathy
• Heart Failure

Intervention

Procedure:
• cardiobiopsy
5 samples will be taken from right ventricle by Cordis bioptome

Locations

Country	Name	City	State
Poland	Central Hospital of Ministry of Internal Affairs and Administration	Warsaw

Sponsors (2)

Lead Sponsor	Collaborator
Ministry of Scientific Research and Information Technology, Poland	Polish Academy of Sciences

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	all cause mortality		one year	No
Secondary	qualitative differences in desmin expression in cardiomyocytes of patient with heart failure		one year	No