Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation
This study will be investigating the effect of latent tuberculosis infection (LTBI) treatment
on glucose tolerance and low-grade inflammation.
Almost a century ago, researchers proposed that diabetes (DM) was associated with increased
risk of Tuberculosis infection (TB). A more recent systematic review concluded that DM
increases the relative risk for TB 3.1 times. Reversely, TB may affect the glycaemic control;
TB is in many cases a chronic infection characterised by long term low-grade inflammation and
weight loss, and persons with TB are known to be at risk of hyperglycaemia and DM at time of
diagnosis.
A latent infection with the m.tuberculosis bacteria is "silent" without symptoms. 1,7 billion
have LTBI on a global scale. Event though the infected person does not experience symptoms,
increased background inflammation has been shown in LTBI patients in previous studies. We
also know that an increase in inflammatory markers precedes clinical development of DM, and
that sub-clinical inflammation contributes to insulin resistance.
We hypothesise that LTBI contributes to dysregulated glucose metabolism due to increased
low-grade inflammation, and that treatment will reduce low-grade inflammation and improve
glucose tolerance.
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