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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02928939
Other study ID # 2016-00525
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 2016
Est. completion date April 2021

Study information

Verified date April 2021
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.


Description:

The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.


Recruitment information / eligibility

Status Completed
Enrollment 1101
Est. completion date April 2021
Est. primary completion date August 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Inpatients at the University Hospital Zurich, USZ - Male and female patients, aged 18 years or older - Fulfilling the criteria for Use Case A or B (i.e. patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs, Use Case A or patients with diabetes mellitus and/or systemic corticosteroids, Use Case B) Exclusion Criteria: - If potential participants have a statement in the electronic medical record or elsewhere to refuse study participation, this represents exclusion criteria.

Study Design


Intervention

Other:
drug-drug or drug-disease interaction


Locations

Country Name City State
Switzerland University Hospital Zurich Zurich

Sponsors (3)

Lead Sponsor Collaborator
University of Zurich Center of Competence Multimorbidity, Zurich, University Hospital, Zürich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type Measure Description Time frame Safety issue
Primary Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs Do anticoagulants or antiplatelet drugs increase the risk of repeated bleeding in patients with gastrointestinal bleeding? 5 years
Primary Patients with diabetes mellitus and systemic corticosteroids Do systemic corticosteroids increase the risk of exacerbation in patients with diabetes mellitus? 5 years
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