Diabetes Mellitus Clinical Trial
Official title:
Comparison of Ultrasound-Guided Axillary Brachial Plexus Block Properties in Diabetic and Non-diabetic Patients: A Prospective Observational Study
Background and objectives: The investigators performed this study to explore whether the
presence of diabetes mellitus (DM) would affect the outcomes of axillary brachial plexus
blocks (ABPBs) in patients undergoing elective forearm and/or hand surgery. The primary
hypothesis was that the sensory block duration would be delayed in diabetic patients.
Methods: After obtaining ethics committee approval and written informed consent, 71 patients
were enrolled to the study. Diabetic patients were included in Group DM and non-diabetics
were included in Group NODM. All received ultrasound-guided ABPBs with the mixture of 10 mL
lidocaine 2% and 20 mL bupivacaine 0.5%. Our primary outcome was sensory block duration, and
secondary outcomes were sensory and motor block onset times, motor block duration,
time-to-first-pain (numeric rating scale (NRS) ≥4), postoperative NRS scores and rescue
analgesic consumption (NRS) ≥4) through the postoperative first 2 days. All outcomes were
assessed by a blinded investigators.
Background and objectives: The impact of diabetes mellitus (DM) on the practice of
peripheral nerve block anesthesia was mostly investigated in animal researches, and effects
on human models are required to be clarified. The investigators performed this study to
explore whether the presence of DM would affect the outcomes of axillary brachial plexus
blocks (ABPBs) in patients undergoing elective forearm and/or hand surgery. The primary
hypothesis was that the sensory block duration would be delayed in diabetic patients.
Methods: After obtaining ethics committee approval and written informed consent, 71 patients
with American Society of Anesthesiologists (ASA) physical status I-III and aged between 40
and 75 years were enrolled to the study. Diabetic patients were included in Group DM and
non-diabetics were included in Group NODM. All received ultrasound-guided ABPBs with the
mixture of 10 mL lidocaine 2% and 20 mL bupivacaine 0.5%. Postoperatively, patients were
administered paracetamol as rescue analgesics, if numeric rating scale (NRS) was ≥4. Our
primary outcome was sensory block duration, and secondary outcomes were sensory and motor
block onset times, motor block duration, time-to-first-pain (numeric rating scale (NRS) ≥4),
postoperative NRS scores, and rescue analgesic consumption (NRS) ≥4) through the
postoperative first 2 days. All outcomes were assessed by a blinded investigators.
;
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