Depression Clinical Trial
Official title:
Randomized Double-blind Placebo-controlled Trial of Ketamine Given During Propofol Sedation in Patients With Chronic Pain and Depression
The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during sedation in adults with chronic pain and depression. This study aims to: - Evaluate whether ketamine is more effective than a placebo in treating chronic pain and depression - Confirm that propofol sedation is a safe way to keep participants blinded to treatment - Assess patients' comfort with the sedation process to improve future studies - Explore whether patient expectations affects their pain and depression Participants will: - Need to qualify for the study based on stringent medical criteria - Undergo sedation with propofol - Randomly receive either a ketamine or a placebo (saline) infusion during sedation - Complete several study assessments over 5-7 weeks
Ketamine is a dissociative anesthetic that has been in clinical use for more than 50 years. In addition to its well-known anesthetic and pain-relieving properties, ketamine has repeatedly been found to have fast-acting antidepressant effects in patients with depression. However, the mechanisms underlying ketamine's ability to treat chronic pain and depression are poorly understood. A most basic question regarding ketamine's therapeutic mechanism is still unresolved: do patients need to consciously experience ketamine's acute dissociative effects to receive lasting analgesic and antidepressant benefits? In this clinical trial, participants will receive either ketamine or a placebo when they are under sedation with propofol. ;
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