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NCT05526131 Clinical Trial

BDNF Level and val66met Polymorphism of Brain Derived Neurotropic Factor Gene in Patients With T2DM and Depression

Depression Clinical Trial

Official title:
Brain Derived Neurotropic Factor Level and val66met Polymorphism of Brain Derived Neurotropic Factor Gene in Patients With Type Two Diabetes Mellitus and Depression

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05526131
Other study ID # KA-239-D
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date February 17, 2021
Est. completion date October 23, 2021

Study information
Verified date August 2022
Source Kasr El Aini Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to studying the relationship between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.

Description:

The study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders. Genotyping was performed by using Real Time-PCR (TaqMan probes).

Recruitment information / eligibility
Status Completed
Enrollment 88
Est. completion date October 23, 2021
Est. primary completion date September 20, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Adult patients who have type two diabetes with or without depression.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Questionare
Assessing the presence or the absence of depression: By structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders.

Locations
Country Name City State
Egypt Cairo university hospitals Cairo

Sponsors (1)
Lead Sponsor Collaborator
Kasr El Aini Hospital

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary BDNF level in blood Measurement of the level of BDNF in blood 1 day (At the time of recruitment)
Primary val66met polymorphism of BDNF gene Measurement of val66met polymorphism of BDNF gene 1 day (At the time of recruitment)
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