Development of a Predictive Index for Probable Depression Among Secondary School Students

Depression Clinical Trial

Official title:

A Longitudinal Study for Identifying Predictors of Incidence/Remission of Probable Depression and Developing a Predictive Index for Probable Depression Among Secondary School Students

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04063202
• Other study ID #: HMRF16171001
• Status: Recruiting
• Start date: October 30, 2020
• Est. completion date: August 2023

Study information

• Verified date: March 2022
• Source: Chinese University of Hong Kong
• Contact: Xue Yang, PhD
• Phone: +852 2252 8740
• Email: sherryxueyang[@]cuhk.edu.hk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The present study aims to develop a new predictive index to predict future depression of adolescents by using factors including individual, interpersonal and environmental. The index can be used to predict likelihood of students who are non-probable depression cases convert into probable depression cases. In addition, the investigators also test the factors of depression remission. It can hence be used in school setting to identify high-risk students, and provide them with secondary interventions that are designed by considering modifiable significant variables identified in this unique, large-scale, longitudinal study.

Description:

A 12-month longitudinal study will be conducted in secondary school settings.

The investigators will investigate incidence of probable depression (i.e., from non-depression, CESD<16, at baseline to probable depression, CESD≥16, at month 12) and remission of probable depression.

The investigators will investigate factors that can prospectively predict new cases/remission of probable depression, including both well-documented risk/protective factors and some under-examined but potentially important local factors (e.g. school/academic stress, psychological resilience). The relative importance of the risk/protective factors at different socio-ecological levels will be compared and their combined effect will be identified.

Based on the selected factors, the investigators will derive a new prediction index called the Adolescent Depression Prediction Index (ADPI) in a model building sample and test its performance in predicting incidence of depression in a validation sample among secondary school students in Hong Kong.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 4799
• Est. completion date: August 2023
• Est. primary completion date: August 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Years to 16 Years

Eligibility

Inclusion Criteria:

• Secondary 1 (seventh year of formal education) to Secondary 4 Chinese students, who are studying local mainstream schools in Hong Kong.

• Able to read Chinese and speak either Cantonese or Mandarin.

Exclusion Criteria:

• Eligible students whose parents refuse to give consent to take part in the study.

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Stress
• Youth

Intervention

Other:
• Observation
The anonymous structured questionnaire will be self-administered by the participating students in the absence of their teachers in class-room settings.

Locations

Country	Name	City	State
Hong Kong	China Holiness Church Living Spirit College	Hong Kong
Hong Kong	Christian Alliance SW Chan Memorial College (Christian Alliance SW Chan Memorial Secondary School)	Hong Kong
Hong Kong	Ho Ngai College ( Sponsored By Sik Sik Yuen)	Hong Kong
Hong Kong	Kit Sam Lam Bing Yim Secondary Schoo	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of probable depression	To examine the incidence of probable depression from non-depression (CESD<16) at baseline to probable depression (CESD>=16) at month 12.	12 months
Primary	Adolescent Depression Prediction Index (ADPI)	To develop a new prediction index ADPI and test test its performance in predicting incidence of depression.	12 months