Depression Clinical Trial
Official title:
Treatment of Sleep Disturbances in Trauma-affected Refugees: A Randomised Controlled Trial
The overall aim of this study is to examine the effects of sleep enhancing treatment in refugees with PTSD.
BACKGROUND:
Sleep disturbances are often referred to as a hallmark of PTSD. In a sample of 734
trauma-affected refugees undergoing psychiatric treatment at Competence Centre for
Transcultural Psychiatry (CTP) in the period 2008-2012 99% reported sleep disturbances and
nightmares.
In trauma-affected populations untreated sleep disturbances can uphold and exacerbate both
sleep-related and non-sleep-related PTSD symptoms. Sleep disturbances may also affect the
efficacy of first-line PTSD treatment and constitute a risk factor for poor outcome of
psychiatric treatment. It has been argued that effective treatment of sleep disturbances may
accelerate recovery in PTSD. There is a lack of randomised clinical trials on this relation
in trauma-affected refugees.
The aim of this study is to examine sleep enhancing treatment in refugees with PTSD.
MATERIALS AND METHOD:
The study will include 230 refugees, diagnosed with PTSD, referred to CTP. Patients who give
informed consent will be randomised to four treatment groups.
1. Treatment as usual (TAU); pharmacological treatment according to algorithm and manual
based Cognitive Behavioural Therapy
2. TAU and add-on treatment with mianserin
3. TAU and add-on treatment with Imagery Rehearsal Therapy (IRT)
4. TAU and add-on treatment with mianserin and IRT
RESULTS:
This study is expected to bring forward new knowledge on both medical and therapeutic
treatment of sleep disturbances in trauma-affected refugees.
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