Optimizing Medication Management for Mothers With Depression

Depression Clinical Trial

— OPTI-MOM  

Official title:

Optimizing Medication Management for Mothers With Depression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02519790
• Other study ID #: 1U54HD085601-01
• Status: Completed
• Start date: August 2016
• Est. completion date: June 30, 2021

Study information

• Verified date: November 2021
• Source: Northwestern University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to explore the way the antidepressant concentration (amount of medication) in the blood changes due to the physiological changes in the body (i.e., changes in metabolism, hormones and body fluid) during pregnancy and postpartum and the impact of genetic factors on the degree of these changes. Changes in antidepressant concentration are important to monitor, as decreases in antidepressant concentration may lead to less than therapeutic drug levels, which may cause an increase in mood symptoms or recurrence of depressive episodes. Increases in antidepressant concentration have the potential to lead to increased side effects. The study team is hoping to better understand the course of these changes across pregnancy and postpartum and how an individual's genetic makeup impacts these changes with the goal of developing guidelines to optimize antidepressant treatment of pregnant women.

Description:

The overarching goal of this The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) funded U54 Obstetric-Fetal Pharmacology Research Center study is to develop evidence to construct guidelines for the optimal use of selective serotonin reuptake inhibitor (SSRI) antidepressants in pregnant women. The progressive changes in plasma SSRI and metabolite concentrations across pregnancy and after birth will be determined in an observational study. Serial evaluations of depressive and anxiety symptoms and side effects will be obtained to evaluate their association with plasma concentrations at monthly intervals during pregnancy and twice post-birth. To assess the subjects' metabolic phenotypes, subjects have the option to receive a probe drug cocktail, which will be given to evaluate the activities of enzymes involved in antidepressant metabolism during the third trimester (when activity change is maximal) compared to the non-pregnant state after birth.

Additionally, the study team will investigate the impact of genomic variability on inter-individual differences in SSRI dosing, plasma concentrations and pharmacodynamics during pregnancy, with a focus on genes involved in the metabolism and elimination of SSRIs, drug transporters responsible for SSRI access to the central nervous system, and genes encoding critical SSRI targets involved in therapeutic efficacy.

Finally, the study team will determine the maternal-fetal plasma concentrations and pharmacogenetic characteristics associated with neonatal SSRI abstinence syndrome. Maternal and fetal genotypes will be assessed for their relationship to SSRI drug concentrations and neonatal abstinence syndrome.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 88
• Est. completion date: June 30, 2021
• Est. primary completion date: December 2020
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Age 18-45

• Pregnant, less than or at 18 weeks gestation

• English-speaking

• DSM-IV diagnosis of Major Depressive Disorder (MDD), any subtype

• Medically healthy

• Singleton gestation

• Taking sertraline (Zoloft), fluoxetine (Prozac), or citalopram (Celexa)/escitalopram (Lexapro) and have made the decision to continue this medication throughout pregnancy

Exclusion Criteria:

• DSM-IV diagnosis of bipolar disorder or any psychotic episode

• Substance abuse or dependence in the last 6 months and/or positive urine drug screen

• Primary anxiety disorder without MDD

• EPDS score =15, or item 10, self-harm thoughts, is scored 3 "yes, quite often"

• Current use of other therapies for depression, including herbals (such as St. John's Wort)

• Chronic use of drugs for medical disorders except aspirin

• Allergy or adverse reaction to dextromethorphan, omeprazole, midazolam or tolbutamide (exclusion for probe study only; these individuals may still participate in the main study)

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Pregnancy

Locations

Country	Name	City	State
United States	Northwestern University Asher Center for the Study and Treatment of Depressive Disorders	Chicago	Illinois
United States	University of Texas Medical Branch	Galveston	Texas
United States	Marshfield Clinic	Marshfield	Wisconsin
United States	University of Pittsburgh	Pittsburgh	Pennsylvania

Sponsors (4)

Lead Sponsor	Collaborator
Northwestern University	Marshfield Clinic, The University of Texas Medical Branch, Galveston, University of Pittsburgh

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concentration-to-dose ratio of SSRI in plasma		Every 4 weeks in pregnancy, at delivery, and at 6 and 14 weeks postpartum
Secondary	Edinburgh Postnatal Depression Scale (EPDS) Scores		Every 4 weeks in pregnancy, at delivery, and at 6 and 14 weeks postpartum
Secondary	Asberg Side Effects Scale		Every 4 weeks in pregnancy and at 6 and 14 weeks postpartum